A ratiometric fluorescent probe of methionine sulfoxide reductase with an improved response rate and emission wavelength.

Chem Commun (Camb)

State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.

Published: January 2019

AI Article Synopsis

  • - A new fluorescent probe called Msr-Ratio has been developed to monitor the activity of the enzyme methionine sulfoxide reductase in both lab settings and live cells.
  • - The probe shows impressive features, including a 400-fold increase in fluorescence, a quick response time of less than 30 minutes, and a significant Stokes shift of 120 nm.
  • - It emits green light at 550 nm, making it a useful tool for studying enzyme activity effectively.

Article Abstract

A ratiometric fluorescent probe of methionine sulfoxide reductase, Msr-Ratio, was disclosed for monitoring the enzyme activity in vitro and in live cells. The probe displayed favorable properties such as a nearly 400-fold fluorescence change, fast response rate (<30 min), large Stokes shift (120 nm), and green emission (550 nm).

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Source
http://dx.doi.org/10.1039/c8cc08879aDOI Listing

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