The ALK inhibitor AZD3463 effectively inhibits growth of sorafenib-resistant acute myeloid leukemia.

Blood Cancer J

Division of Translational Cancer Research, Department of Laboratory Medicine, Lund University, Lund, Sweden.

Published: January 2019

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333797PMC
http://dx.doi.org/10.1038/s41408-018-0169-1DOI Listing

Publication Analysis

Top Keywords

alk inhibitor
4
inhibitor azd3463
4
azd3463 effectively
4
effectively inhibits
4
inhibits growth
4
growth sorafenib-resistant
4
sorafenib-resistant acute
4
acute myeloid
4
myeloid leukemia
4
alk
1

Similar Publications

Alectinib treatment for 2 non-small cell lung carcinoma patients carrying different novel fusions.

Zhong Nan Da Xue Xue Bao Yi Xue Ban

July 2024

Department of Pathology, Second Xiangya Hospital, Central South University, Changsha 410011.

The genomic fusions of the anaplastic lymphoma kinase () gene have been widely recognized as effective therapeutic targets for non-small cell lung carcinoma (NSCLC). The Second Xiangya Hospital of Central South University has treated 2 NSCLC patients with 2 distinct novel gene fusions. Case 1 was a 55-year-old male with a solid nodule located in the right hilar lobe on enhanced CT scan.

View Article and Find Full Text PDF

We report a case showing that lorlatinib is effective in treating EML4-ALK-positive low-grade serous ovarian cancer (LGSO) with intracranial metastasis. This may be the first clinical evidence of LGSO benefit from ALK inhibitors, to provide evidence for the use of ALK inhibitors in more ovarian cancer patients with EML4-ALK fusion and promoting new ideas for the study of EML4-ALK targets in ovarian cancer.

View Article and Find Full Text PDF

Targeted covalent inhibitors (TCIs) play an essential role in the fields of kinase research and drug discovery. Most existing TCIs are however cysteine- or lysine-reactive, thus severely limiting their potential applications. New types of TCIs capable of covalently targeting other nucleophilic amino acids that are readily available in proteins are urgently needed.

View Article and Find Full Text PDF

Non-small-cell lung cancer (NSCLC) is a highly heterogeneous disease that is frequently associated with a host of known oncogenic alterations. Advances in molecular diagnostics and drug development have facilitated the targeting of novel alterations such that the majority of NSCLC patients have driver mutations that are now clinically actionable. The goal of this review is to gain insights into clinical research and development principles by summary, analysis, and discussion of data on agents targeting known alterations in oncogene-driven, advanced NSCLC beyond those in the and the .

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!