Objectives: To assess pediatric providers' perceptions on viral testing and to determine barriers to minimizing respiratory viral testing (RVT) in bronchiolitis.
Methods: A single-center, cross-sectional study was conducted and included 6 focus group discussions with pediatric providers. Questions were focused on identifying factors associated with obtaining RVT. Focus group discussions were transcribed verbatim and coded for emergent themes.
Results: Clinicians report that they themselves do not typically obtain RVT in otherwise healthy patients with bronchiolitis. The most commonly cited reasons for not obtaining RVT is that it does not aid medical decision-making and that it is used as an educational opportunity for trainees. However, clinicians tend to obtain RVT when they are directed by another clinician, when they desire reassurance, when RVT is perceived as "doing something," and when there are knowledge gaps on institutional cohorting policies.
Conclusions: Clinician medical decision-making is influenced by multiple internal and external factors. Intended behaviors do not always correlate with actual actions because of these influences. Developing interventions in which some of these factors are addressed may help reduce unnecessary RVT among healthy patients with bronchiolitis and could be considered for broader application beyond this patient population.
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http://dx.doi.org/10.1542/hpeds.2018-0108 | DOI Listing |
Sci Rep
December 2024
Department of Ecology, Faculty of Sciences, Institute of Biology, University of Pécs, Ifjúság útja 6, Pécs, 7624, Hungary.
The European pond turtle (Emys orbicularis) is a wide-ranging, long-living freshwater species with low reproductive success, mainly due to high predation pressure. We studied how habitat variables and predator communities in near-natural marshes affect the survival of turtle eggs and hatchlings. We followed the survival of artificial turtle nests placed in marshes along Lake Balaton (Hungary) in May and June as well as hatchlings (dummies) exposed in September.
View Article and Find Full Text PDFSci Rep
December 2024
Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
The Epstein-Barr virus (EBV) is widespread and has been related to a variety of malignancies as well as infectious mononucleosis. Despite the lack of a vaccination, antiviral medications offer some therapy alternatives. The EBV BZLF1 gene significantly impacts viral replication and infection severity.
View Article and Find Full Text PDFNat Commun
December 2024
KU Leuven Department of Microbiology, Immunology and Transplantation, Virology, Antiviral Drug & Vaccine Research Group, Rega Institute for Medical Research, Leuven, Belgium.
The 2015-2016 Zika virus (ZIKV) outbreak in the Americas revealed the ability of ZIKV from the Asian lineage to cause birth defects, generically called congenital Zika syndrome (CZS). Notwithstanding the long circulation history of Asian ZIKV, no ZIKV-associated CZS cases were reported prior to the outbreaks in French Polynesia (2013) and Brazil (2015). Whether the sudden emergence of CZS resulted from an evolutionary event of Asian ZIKV has remained unclear.
View Article and Find Full Text PDFNat Commun
December 2024
Boyd Orr Centre for Population and Ecosystem Health, School of Biodiversity, One Health & Veterinary Medicine, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, UK.
Rabies is a viral zoonosis that kills thousands of people annually in low- and middle-income countries across Africa and Asia where domestic dogs are the reservoir. 'Zero by 30', the global strategy to end dog-mediated human rabies, promotes a One Health approach underpinned by mass dog vaccination, post-exposure vaccination of bite victims, robust surveillance and community engagement. Using Integrated Bite Case Management (IBCM) and whole genome sequencing (WGS), we enhanced rabies surveillance to detect an outbreak in a formerly rabies-free island province in the Philippines.
View Article and Find Full Text PDFClin Transplant
January 2025
Division of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Background: Early posttransplant cytomegalovirus (CMV) infections in CMV seronegative solid organ transplant recipients (SOTR) with CMV seronegative donors (D-/R-) are often attributed transfusion-transmitted CMV. The prevalence of false-negative donor CMV serology in D-/R- SOTR with early CMV infections has not been explored.
Methods: We determined the frequency and characteristics of CMV DNAemia that occurred within 90 days of transplant among adult SOTR classified as D-/R- who underwent a first SOT at a single center between February 25, 2014 and February 25, 2024.
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