AI Article Synopsis
- The study investigates the potential benefits of DHEA treatment for women undergoing IVF or ICSI with poor ovarian response (POR), who typically have low pregnancy success rates.
- The trial is a multicenter, double-blind, placebo-controlled study, where participants will be randomly assigned to receive either DHEA or a placebo for 4-12 weeks prior to their treatment.
- The primary goal is to assess the live birth rate, aiming to provide clearer evidence on the effectiveness of DHEA for improving IVF outcomes in women with POR.
Article Abstract
Background: Women undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) with poor ovarian respond (POR) always have very low clinical pregnancy rates. In previous data, dehydroepiandrosterone (DHEA) was suggested as a promising treatment and maybe has a good pregnancy outcome. But there is no sufficient evidence from randomized clinical trials evaluating the effect of DHEA preconceptional treatment on live birth in POR.
Methods: This trial is a multicenter active-placebo double-blind clinical trial (1:1 treatment ratio of active versus placebo). The infertile POR patients undergoing IVF or ICSI will be enrolled and randomly assigned to two parallel groups. Participants in these two groups will be given 4-12 weeks' treatment of DHEA or placebo, respectively. The primary outcome is live birth rate.
Discussion: The results of this study will provide evidence for the effect of preconceptional DHEA treatment on IVF outcome in POR.
Trial Registration: Chinese Clinical Trial Registry, ChiCTR-IPR-15006909 . Registered on November 9, 2015.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334415 | PMC |
| http://dx.doi.org/10.1186/s13063-018-3146-x | DOI Listing |
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Article Synopsis
- The study investigates the potential benefits of DHEA treatment for women undergoing IVF or ICSI with poor ovarian response (POR), who typically have low pregnancy success rates.
- The trial is a multicenter, double-blind, placebo-controlled study, where participants will be randomly assigned to receive either DHEA or a placebo for 4-12 weeks prior to their treatment.
- The primary goal is to assess the live birth rate, aiming to provide clearer evidence on the effectiveness of DHEA for improving IVF outcomes in women with POR.
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