One hundred and twenty seven cases of cervical lymph node infection were seen between 1974 and 1986 in children aged between 1 month and 10 years. The point of origin of the infection wa identified in 30% of cases and was, in decreasing order: cutaneous, in the cervico-cephalic region; pharyngo-tonsillar via the lymphatic structures of the pharynx or by direct effraction of the buccopharyngeal mucosa; and, finally, dental. The site of the secondary lymph node infection was generally below and behind the angle of the jaw and in some cases submandibular. Two thirds of cases progressed to suppuration and were evaluated bacteriologically. Four organisms were identified: Staphylococcus, very much in the majority. The origin of the infection was almost always cutaneous. There was a predilection for the child aged under 5 with a majority under 2. The streptococcus was in second place far behind the staphylococcus. The origin of the infection was pharyngo-tonsillar, with the beta-haemolytic streptococcus predominant, bucco-dental, with the alpha-haemolytic predominant, and a very small number of cases with a cutaneous origin. The age of these children was greater than in the staphylococcal infection group: the great majority were over 2 and all cases with a dental origin were aged over 5. There were a small number of anaerobic infections. In 2 of the 3 bacteriologically confirmed cases, the origin was pharyngo-tonsillar and development was obviously favored by the initial antibiotics prescribed. Management took into account the predominance of the staphylococcus, the resistance of this organism to penicillin G and its usual sensitivity to methicillin.(ABSTRACT TRUNCATED AT 250 WORDS)
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J Pathol Clin Res
January 2025
Department of Urology, University of Duisburg-Essen, Essen, Germany.
Distinct molecular subtypes of muscle-invasive bladder cancer (MIBC) may show different platinum sensitivities. Currently available data were mostly generated at transcriptome level and have limited comparability to each other. We aimed to determine the platinum sensitivity of molecular subtypes by using the protein expression-based Lund Taxonomy.
View Article and Find Full Text PDFWorld J Gastrointest Oncol
January 2025
Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest 050474, Romania.
Background: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive lethal malignancy with limited options for treatment and a 5-year survival rate of 11% in the United States. As for other types of tumors, such as colorectal cancer, aberrant lipid synthesis and reprogrammed lipid metabolism have been suggested to be associated with PDAC development and progression.
Aim: To identify the possible involvement of lipid metabolism in PDAC by analyzing in tumoral and non-tumoral tissues the expression level of the most relevant genes involved in the long-chain fatty acid (FA) import into cell.
World J Gastrointest Oncol
January 2025
Department of Gastrointestinal Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China.
Background: Colorectal cancer (CRC) is a prevalent malignant neoplasm characterized by subtle early manifestations.
Aim: To investigate the correlation among serum lipid profiles, the triglyceride-glucose (TyG) index, and the atherosclerotic index (AI) in patients with CRC. Furthermore, it explored the clinical diagnostic utility of combining serum lipids with cancer antigens in the context of CRC.
World J Gastrointest Oncol
January 2025
Department of Orthopaedics, Air Force Hospital of Eastern Theater, Anhui Medical University, Nanjing 230032, Jiangsu Province, China.
Background: Previous cellular studies have demonstrated that elevated expression of Cx43 promotes the degradation of cyclin E1 and inhibits cell proliferation through ubiquitination. Conversely, reduced expression results in a loss of this capacity to facilitate cyclin E degradation. The ubiquitination and degradation of cyclin E1 may be associated with phosphorylation at specific sites on the protein, with Cx43 potentially enhancing this process by facilitating the phosphorylation of these critical residues
Aim: To investigate the correlation between expression of Cx43, SKP1/Cullin1/F-box (SCF), p-cyclin E1 (ser73, thr77, thr395) and clinicopathological indexes in colon cancer.
J Arrhythm
February 2025
Department of Electrophysiology, Department of Cardiology AIG Institute of Cardiac Sciences and Research Hyderabad India.
Objectives: We present a case series of patients with granulomatous myocarditis presenting as atrial arrhythmias accompanied by lymphadenopathy.
Background: Atrial myocarditis (AM) may be the cause of atrial fibrillation (AF) in patients without risk factors.
Methods: Patients with atrial fibrillation without risk factors underwent 18F-Fluorodeoxyglucose positron emission tomography (18F-FDG-PET).
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