AI Article Synopsis
- N-methyladenosine (m A) is the most common RNA epigenetic modification, influencing key biological functions and mRNA metabolism.
- Recent studies have identified enzymes that add (writers) and remove (erasers) m A, as well as "readers" like various proteins that determine how mRNA is utilized.
- This review highlights the latest findings on m A's role in RNA metabolism, cancer, lipid metabolism, and explores the fundamental molecular mechanisms involved.
Article Abstract
N -methyladenosine (m A), as the most abundant RNA epigenetic modifications, has been shown to play critical roles in various biological functions. Research about enzymes that can catalyze and remove m A have revealed its comprehensive roles in messenger RNA (mRNA) metabolism and other physiological processes. The "readers" including YTH domain-containing proteins, hnRNPC, hnRNPG, hnRNPA2B1, IGF2BP1, IGF2BP2, and IGF2BP3, which can affect the fates of mRNA in an m A-dependent manner. In this review, we focus on recent advances in the research of the m A modifications, especially about the latest functions of its writers, erasers, readers in RNA metabolism, cancer, and lipid metabolism. In the end, we provide insights into the underlying molecular mechanisms of m A modifications.
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| http://dx.doi.org/10.1002/jcp.28014 | DOI Listing |
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