AI Article Synopsis
- The study aimed to evaluate how effective and safe Infliximab is in preventing postoperative recurrence in Crohn's disease patients through a meta-analysis of clinical trials.
- A total of 7 high-quality prospective trials involving 455 patients were analyzed, showing that Infliximab significantly reduced both endoscopic and clinical recurrence rates compared to placebo, with no major reported side effects.
- The findings suggest that Infliximab is an effective and well-tolerated treatment option for managing Crohn's disease in postoperative patients.
Article Abstract
Objective: We sought to investigate the efficacy and safety of Infliximab for prevention of postoperative recurrence in patients with Crohn's disease (CD), in a meta-analysis of clinical trial results.
Methods: The Medline, Embase, PubMed, and Web of Science databases were systematically searched for suitable studies. A meta-analysis of enrolled studies was performed to analyze the efficacy of Infliximab on outcomes regarding the prevention of postoperative recurrence of CD. A Galbraith radial plot was used to quantify the heterogeneity. Funnel plot and Egger test were performed to describe the bias of publication. A Forest plot was prepared to indicate the efficacy outcomes.
Results: A total of 7 prospective trials were included in our meta-analysis (N=455). The Funnel plot and Egger test showed there was no significant bias in the included publications. The Cochrane collaboration tool indicated that all 7 prospective trials were of high quality. The results of Galbraith radial plot showed that no study was the source of heterogeneity. Compared with the placebo group, Infliximab decreased the rates of endoscopic recurrence (RR =0.421; 95% CI 0.328 to 0.539; <0.001), and there was a significant reduction in rates of clinical recurrence in the Infliximab-treated group (RR =0.519; 95% CI 0.349 to 0.774; =0.001). Furthermore, Infliximab treatment did not show adverse effects as other systematic therapeutic drugs, indicating that Infliximab treatment is effective and well tolerated.
Conclusion: Compared with the controls, Infliximab is a promising therapeutic agent for the management of CD patients.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311309 | PMC |
| http://dx.doi.org/10.1155/2018/2615978 | DOI Listing |
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