AI Article Synopsis
- Bowen's disease (BD) is a rare type of skin cancer with low invasive potential, and the combination of cryosurgery and ingenol mebutate (IM) has shown promising results for treatment.
- The study involved 4 patients (average age 76.5 years) who underwent a cryosurgery session followed by 4 days of IM treatment, leading to excellent healing with no relapses after 12 months.
- Optical coherence tomography (OCT) was used for monitoring treatment, showing significant improvements in skin structure post-treatment, indicating this combined approach warrants further investigation.
Article Abstract
Bowen's disease (BD) is a relatively rare squamous cell carcinoma (SCC) with a limited potential of becoming invasive. Ingenol mebutate (IM) was relatively successful for the treatment of BD lesions in small case series. Optical coherence tomography (OCT) is a promising method for the diagnosis of cutaneous keratinocytic carcinomas, including BD. Herein we report the treatment of BD with the combination of cryosurgery and IM and the application of OCT imagining in treatment monitoring. Patients treated within a period of 12 months are retrospectively compiled. Treatment consisted of a mild cryosurgery session (liquid N, open spray, and 2 freeze-thaw cycles of 15 sec each) of a field including the BD lesion and a 0.5cm rim and IM application for 4 consecutive days starting at the cryosurgery day. Four patients (3 females; average age: 76.5 years) with 4 lesions (20-70mm maximal diameter; average 36.2mm) were included. Healing was excellent and no relapse was observed at 12 months' follow-up. Baseline OCT revealed a disarranged, thickened epidermis, while a normally layered epidermis overlying a hyperreflective dermis was present after treatment. Conclusively, the combination of cryosurgery followed by IM is a feasible, effective treatment for BD that should be evaluated in further studies.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311265 | PMC |
| http://dx.doi.org/10.1155/2018/9423949 | DOI Listing |
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