Aim: We aimed to explore the prognostic implications of adiponectin (APN) levels in the serum and bronchoalveolar lavage (BAL) of patients with advanced NSCLC.
Materials & Methods: 29 newly diagnosed patients with stage IV NSCLC were prospectively enrolled. Baseline serum and BAL levels of APN were assayed by ELISA and correlated with various clinicopathological parameters, including overall survival.
Results: No statistically significant correlations were observed between the serum or BAL levels of APN and the clinicopathological parameters evaluated. The only prognostic factor identified, both by univariate and multivariate survival analyses, was performance status.
Conclusion: The results of our cohort failed to reveal any prognostic significance of serum and BAL levels of APN in stage IV NSCLC.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310335 | PMC |
| http://dx.doi.org/10.2217/lmt-2016-0018 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Retinoic acid-adjuvanted vaccine induces antigen-specific secretory IgA in the gut of newborn piglets.
Vaccine
December 2024
Infectious Disease Immunology, Center for Vaccine Research, SSI, Copenhagen, Denmark. Electronic address:
Mucosal secretory IgA (SIgA) produced by subepithelial plasma cells in the lamina propria is the major antigen-specific defense mechanism against mucosal infections. We investigated if a retinoic acid (RA)-containing adjuvant in parenteral immunization, can induce vaccine-specific SIgA in the jejunal lumen in a dose-dependent manner in neonatal pigs immunized with a Chlamydia hybrid antigen. To accurately quantify SIgA responses in mucosal secretions, an antigen-specific ELISA method with secondary detection of porcine secretory component rather than IgA was developed.
View Article and Find Full Text PDF(1, 3)-beta-D-Glucan in bronchoalveolar lavage fluid: a useful biomarker in diagnosis of invasive pulmonary infection caused by Hormographiella aspergillata?
Diagn Pathol
December 2024
Department of Microbiology, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region, China.
Hormographiella aspergillata is a rare hyaline mold causing invasive fungal infection in humans, until the frequent use of antifungal prophylaxis in immunocompromised hosts. Due to the high mortality of H. aspergillata infection, early recognition and treatment are crucial.
View Article and Find Full Text PDFDelayed Diagnosis of Disseminated Invasive Aspergillosis with Purulent Myocarditis in an Immunocompromised Host.
Infect Dis Rep
November 2024
Department of Internal Medicine and Infectious Diseases, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.
Invasive aspergillosis (IA) is an opportunistic fungal infection that typically occurs in the immunocompromised host and is associated with severe morbidity and mortality. Myocardial abscess formation is seldomly described. We present a case of IA with purulent myocarditis.
View Article and Find Full Text PDFKL‑6, ET‑1 and S100A9 levels in patients with idiopathic pulmonary fibrosis and obstructive sleep apnea.
Exp Ther Med
January 2025
Department of Respiratory Medicine, University of Crete, School of Medicine, 71500 Crete, Greece.
Article Synopsis
- Obstructive sleep apnea (OSA) often occurs alongside idiopathic pulmonary fibrosis (IPF), and specific biomarkers like KL-6, ET-1, and S100A9 may help in diagnosing and understanding the severity of these conditions.
- A study involving 55 participants, including those with IPF and IPF-OSA, measured these biomarker levels and examined their relationship with various health factors.
- Although no significant differences in biomarker levels were found between groups, there were trends suggesting higher ET-1 in IPF-OSA, and significant correlations between KL-6 levels and IPF severity, indicating potential for these biomarkers in identifying OSA impact in IPF patients.
Article Synopsis
- Acute kidney injury (AKI) significantly impacts mortality and morbidity in critically ill patients, and the serum uric acid-to-albumin ratio may serve as a prognostic marker for assessing patient outcomes.
- A study involving over 1,000 ICU patients found that the uric acid-to-albumin ratio effectively predicted 28-day mortality, with specific ratios indicating varied levels of prediction accuracy for both AKI and non-AKI groups.
- The findings suggest that utilizing this affordable biomarker in clinical settings could improve management strategies and better predict outcomes for critically ill patients.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!