AI Article Synopsis
- Foot-and-mouth disease (FMD) is a highly contagious illness that affects cloven-hoofed animals, with multiple virus strains complicating vaccine protection.
- The study evaluates the immunogenicity of a new chimeric vaccine developed from different viral strains, targeting a broad range of FMD virus types, particularly type O.
- This innovative vaccine aims to induce high levels of neutralizing antibodies in pigs, potentially providing effective immunity against the eight known FMD viruses from four major topotypes.
Article Abstract
Foot-and-mouth disease (FMD) is an acute infectious disease occurring in cloven-hoofed animals. There are many variations of the virus, making it difficult to protect against the various strains with one virus vaccine. The immunogenicity has generally been evaluated in pigs using neutralizing antibodies to determine the protection level against foot-and-mouth disease virus type O. Therefore, the vaccine from the chimeric vaccine strain of ME-SA (VP4, VP2, and VP3) and SEA (VP1) topotypes developed in this study is expected to be able to protect with high neutralizing antibody titers against most of the eight FMD viruses of the four different topotypes (ME-SA, SEA, Cathay, and EURO-SA) of type O in pigs. This is a new technique for powerful vaccine development, with multiple preventive roles against various epidemic FMD strains.
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| http://dx.doi.org/10.1016/j.vetmic.2018.12.023 | DOI Listing |
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