AI Article Synopsis
- A new method using fluorescence quenching is proposed for detecting hypochlorite by studying three similar fluorescent coumarins.
- The mechanism involves the chlorination of these coumarins when they react with sodium hypochlorite, which leads to a decrease in their fluorescence intensity.
- This approach indicates that coumarin-based probes can be effectively used for both the detection and quantification of hypochlorite in laboratory settings.
Article Abstract
A fluorescence quenching-based mechanism for the determination of hypochlorite was proposed based on spectroscopic and chromatographic studies on the hypochlorite-sensing potency of three structurally similar and highly fluorescent coumarins. The mode of action was found to rely upon a chlorination of the coumarin-based probes resulting from their reaction with sodium hypochlorite. Importantly, the formation of chlorinated derivatives was accompanied by a linear decrease in the fluorescence intensities of the probes tested. The results obtained suggest the applicability of a coumarin-dependent hypochlorite recognition mechanism for the detection of, as well as for quantitative determination of, hypochlorite species in vitro.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358793 | PMC |
| http://dx.doi.org/10.3390/ijms20020281 | DOI Listing |
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