The association between resting metabolic rate and metabolic syndrome May Be mediated by adipokines in overweight and obese women.

Aims: Adipokines play a major role in developing metabolic syndrome (MetS), and it has been found that there is a significant relationship between MetS and resting metabolic rate (RMR) in obese people. The present study aimed to investigate the mediatory effect of adipokines on the RMR-MetS relationship.

Methods: This cross-sectional study included 263 obese and overweight women, mean BMI 33.28 (4.93) kg/m, and mean age 39.02 (11.60) who were assessed for RMR using indirect calorimetry. Moreover, using the body composition analyzer the Body composition was measured. Also, Enzyme-linked Immunosorbent Assay (ELISA) test provided a quantitative measurement of biochemical parameters.

Results: The results indicated that women in low RMR group had higher fat mass (P < 0.0001), FFM (P = 0.002), weight (P = 0.006), BMI (P < 0.0001), age (P = 0.01), and hs-CRP (P = 0.001). The results did not confirm any significant mediating roles for RBP4 (P = 0.051, β = -0.28) and Vaspin (P = 0.06, β = 0.32) in the RMR-MetS relationship. Additionally, after a binary regression test, Omentin-1 showed a significant mediating role (P = 0.25, β = 0.04) as an interrelated agent to RMR and MetS.

Conclusion: As this study shows, Omentin-1 was found to play a significant mediating role as a mediatory agent in relationship between RMR and MetS.