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[Hepatocellular carcinoma in an inflammatory adenoma with β-catenin mutation in a patient with hepatocellular adenomatosis due to germline mutation in HNF1α]. | LitMetric
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[Hepatocellular carcinoma in an inflammatory adenoma with β-catenin mutation in a patient with hepatocellular adenomatosis due to germline mutation in HNF1α].

Dirk Andreas Ridder Diane Duret Marcus-Alexander Wörns Sebastian Schotten Stefan Heinrich Michael Kloth Erik Springer Wilfried Roth Beate Katharina Straub

Z Gastroenterol

Institut für Pathologie, Universitätsmedizin Mainz.

Published: January 2019

Hepatocyte nuclear factor 1 α (HNF1α) mutations cause maturity-onset diabetes of the young (MODY) type 3 and are associated with hepatocellular adenomatosis. Malignant transformation of HNF1α-mutated hepatocellular adenomas is rare. We report a case of a 28-year-old man with HNF1α-inactivated adenomatosis who developed an inflammatory adenoma with β catenin mutation with malignant transformation into a well-differentiated hepatocellular carcinoma (HCC).

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http://dx.doi.org/10.1055/a-0821-7154DOI Listing

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