Motivation: AtheroEdge Composite Risk Score (AECRS1.0) is an integrated stroke/cardiovascular risk calculator that was recently developed and computes the 10-year risk of carotid image phenotypes by integrating conventional cardiovascular risk factors (CCVRFs). It is therefore important to understand how closely AECRS1.0 is associated with the ten other currently available conventional cardiovascular risk calculators (CCVRCs).
Methods: The Institutional Review Board of Toho University approved the examination of the left/right common carotid arteries of 202 Japanese patients. Step 1 consists of measurement of AECRS1.0 given current image phenotypes and CCVRFs. Step 2 consists of computing the risk score using ten different CCVRCs given CCVR factors: QRISK3, Framingham Risk Score (FRS), United Kingdom Prospective Diabetes Study (UKPDS) 56, UKPDS60, Reynolds Risk Score (RRS), Pooled cohort Risk Score (PCRS or ASCVD), Systematic Coronary Risk Evaluation (SCORE), Prospective Cardiovascular Munster Study (PROCAM) calculator, NIPPON, and World Health Organization (WHO) risk. Step 3 consists of computing the closeness factor between AECRS1.0 and ten CCVRCs using cumulative ranking index derived using eight different statistically derived metrics.
Results: AECRS1.0 reported the highest area-under-the-curve (0.927;P < 0.001) among all the risk calculators. The top three CCVRCs closest to AECRS1.0 were QRISK3, FRS, and UKPDS60 with cumulative ranking scores of 2.1, 3.0, and 3.8, respectively.
Conclusion: AECRS1.0 produced the largest AUC due to the integration of image-based phenotypes with CCVR factors, and ranked at first place with the highest AUC. Cumulative ranking of ten CCVRCs demonstrated that QRISK3 was the closest calculator to AECRS1.0, which is also consistent with the industry trend.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.compbiomed.2019.01.002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Prevalence and associated characteristics of sexual exploitation in a representative sample of spanish youth from an intersectional perspective.
Child Abuse Negl
January 2025
Faculty of Medicine, University of Concepción, Chile.
Background: Child sexual exploitation (CSE) involves using a child or youth as a sexual object in exchange for remuneration, reward, or favors, meeting their survival needs, and also serving the perpetrator's aims for sexual, social, or economic gain.
Objective: The present study addresses the prevalence of CSE in Spain.
Participants: A representative sample of 4024 secondary school adolescents from 14 to 17 years old (M = 15.
Procyanidin-crosslinked gradient silk fibroin composite nanofiber scaffold with sandwich structure for rotator cuff repair.
Biomater Adv
January 2025
Department of Orthopaedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 600 Yishan Rd., Shanghai 200233, PR China. Electronic address:
Improving the regeneration of the tendon-bone interface (TBI) helps to decrease the risk of rotator cuff retears after repair surgeries. Unfortunately, the lack of inherent healing capacity of the TBI, insufficient mechanical properties, and abnormal and persistent inflammation during repair are the key factors leading to suboptimal healing of the rotator cuff. Therefore, a high-strength rotator cuff repair material capable of regulating the unbalanced immune response and enhancing the regeneration of the TBI is urgently needed.
View Article and Find Full Text PDFPervasive Games for Sexual Health Promotion: Scoping Literature Review.
JMIR Serious Games
January 2025
Department of Interactive Visualization and Virtual Reality, Faculty of Engineering, University of Talca, Talca, Chile.
Background: Serious games play a fundamental role in promoting safe sexual behaviors. This medium has great potential for promoting healthy behaviors that prevent potential risk factors, such as sexually transmitted infections, and promote adherence to sexual health treatments, such as antiretroviral therapy. The ubiquity of mobile devices enhances access to such tools, increasing the effectiveness of video games as agents of change.
View Article and Find Full Text PDFLong-Term Intake of Red Meat in Relation to Dementia Risk and Cognitive Function in US Adults.
Neurology
February 2025
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.
Background And Objectives: Previous studies have shown inconsistent associations between red meat intake and cognitive health. Our objective was to examine the association between red meat intake and multiple cognitive outcomes.
Methods: In this prospective cohort study, we included participants free of dementia at baseline from 2 nationwide cohort studies in the United States: the Nurses' Health Study (NHS) and the Health Professionals Follow-Up Study (HPFS).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!