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Restorative properties of chronic lurasidone treatment on emotional dysfunction in rats exposed to chronic unavoidable stress: a role for medial prefrontal cortex - nucleus accumbens network.
Neuropharmacology
January 2025
Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy. Electronic address:
Anhedonia, a transdiagnostic symptom prevalent in depressive and psychotic disorders, poses a significant challenge for pharmacological intervention due to its association with impaired motivation. Understanding how psychotropic drugs can modulate this pathological domain and elucidating the molecular mechanisms underlying such effects are crucial endeavors in psychiatric research. In this study, we aimed to investigate the pro-motivational properties of lurasidone in a rat (Sprague Dawley males) model of anhedonia and to unravel the interplay between lurasidone and the brain regions critical for reward processing.
View Article and Find Full Text PDFCharacterizing the Profile of Anhedonia in Individuals With Schizotypal Traits, Subthreshold Depression and Autistic Traits.
Psych J
January 2025
Neuropsychology and Applied Cognitive Neuroscience Laboratory; CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Anhedonia is believed to be transdiagnostic symptom exist in various disorders including schizophrenia, major depressive disorder, and autism spectrum disorder. However, very few studies attempted to profile subclinical samples with schizophrenia, depressive, and autistic symptoms using measures of anhedonia scales. This study adopted a cluster analytical approach to examine the anhedonia profile in 46 individuals with schizotypal trait (ST), 43 subthreshold depression (SD), 27 autistic trait (AT), and 41 healthy controls.
View Article and Find Full Text PDFBlunted Ventral Striatal Reactivity to Social Reward Is Associated with More Severe Motivation and Pleasure Deficits in Psychosis.
Schizophr Bull
January 2025
Department of Psychology, University of Maryland, College Park, MD 20742, United States.
Background And Hypothesis: Among individuals living with psychotic disorders, social impairment is common, debilitating, and challenging to treat. While the roots of this impairment are undoubtedly complex, converging lines of evidence suggest that social motivation and pleasure (MAP) deficits play a central role. Yet most neuroimaging studies have focused on monetary rewards, precluding decisive inferences.
View Article and Find Full Text PDFMotivation and Pleasure Deficits Undermine the Benefits of Social Affiliation in Psychosis.
Clin Psychol Sci
November 2024
Department of Psychology, University of Maryland, College Park, MD 20742, USA.
Article Synopsis
- In psychotic disorders, deficits in motivation and pleasure (MAP) are linked to problems in social connections and overall functioning.
- A study using a transdiagnostic sample found that people with more negative symptoms experienced less emotional benefit from social interactions, even when they tried to engage with partners.
- Neuroimaging results showed that those with greater MAP deficits had reduced neural responses to comforting physical touch, indicating that these deficits interfere with the positive effects of social support on stress regulation.
Translational assessment of anhedonia components: Significant associations between reward anticipation measured via behavioural task performance, daily smartphone reports, and general anhedonia questionnaires.
Behav Res Ther
January 2025
NIHR Maudsley Biomedical Research Centre, King's College London, UK; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.
Anhedonia, a reduction in pleasure in previously enjoyed activities, is a hallmark feature of depression and is also of transdiagnostic relevance to many psychiatric disorders. Treatment and measurement of anhedonia are significant challenges. We examine anhedonia components, combining experimental training, with multimodal anhedonia assessment, comprising standard questionnaire instruments, a widely-used behavioural task, and daily reports of reward experience.
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