AI Article Synopsis
- - The study focuses on natural compounds called dimycoloyl diarabinoglycerols from mycobacteria, which are important for immune signaling and could help diagnose mycobacterial infections.
- - Researchers successfully synthesized a specific type of compound, diacyl l-glycerol-(1'→1)-β-d-arabinofuranosyl-α-d-arabinofuranosides, using simple fatty acids and precise synthetic mycolic acids.
- - Analysis using NMR confirmed that the synthetic compounds matched the structure of those found in natural mixtures, indicating the effectiveness of the synthesis process.
Article Abstract
Complex mixtures of natural dimycoloyl diarabinoglycerols isolated from mycobacteria have been shown to be both potent immune signalling agents and potentially valuable antigens in the serodiagnosis of mycobacterial infections. We now report the highly stereocontrolled synthesis of diacyl l-glycerol-(1'→1)-β-d-arabinofuranosyl-α-d-arabinofuranosides based on simple fatty acids and single defined synthetic mycolic acids. NMR analysis confirmed that the synthetic core was identical to that in natural mixtures.
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| http://dx.doi.org/10.1016/j.chemphyslip.2019.01.002 | DOI Listing |
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