Linear furocoumarins, also known as psoralens, are clinically useful photo-activated pharmaceuticals employed to address hyperproliferative skin diseases. Seven diverse cytotoxic pharmacophores have been synthetically attached to 8-methoxypsoralen via a 5-amino functionality. The resulting unique set of compounds was evaluated for dark and light toxicity against PAM212 keratinocytes in culture.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364570 | PMC |
| http://dx.doi.org/10.1016/j.bmcl.2018.12.048 | DOI Listing |
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