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| http://dx.doi.org/10.1111/ldrp.12171 | DOI Listing |
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Immunization with extracellular vesicles conjugating inverted influenza HA elicits HA stalk-specific immunity and cross-protection in mice.
Mol Ther
December 2024
Center for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA. Electronic address:
Article Synopsis
- Enhancing immunity in the respiratory tract is vital for fighting influenza through effective mucosal vaccines that can bypass barriers and stimulate immune responses.
- The study used extracellular vesicles (EVs) as a vaccine platform by attaching influenza hemagglutinin (HA) in an upside-down orientation to expose the conserved parts of the virus.
- Results showed that intranasal immunization with these EVs led to strong immune responses in mice, providing protection against various influenza strains and highlighting the potential for developing a universal mucosal vaccine.
Navigating healthcare during a pandemic: what parents of CHD children want healthcare professionals to know.
Cardiol Young
November 2024
School of Nursing, Pacific Lutheran University, Tacoma, WA, USA.
Background: The COVID pandemic has had deleterious effects on the mental health of the global population. Parents of children with CHD were particularly vulnerable to negative mental health outcomes such as depression, anxiety, and perceived stress. A better understanding of the CHD parent experiences, needs, and concerns while navigating the healthcare system during a pandemic is needed.
View Article and Find Full Text PDFMetabolic responses of sea anemone and jellyfish to temperature and UV bleaching: Insights into stress adaptation using LCMS-based metabolomics, molecular networking and chemometrics.
J Adv Res
October 2024
Leibniz Centre for Tropical Marine Research (ZMT), Fahrenheit Str. 6, Bremen 28359, Germany.
Introduction: Climate change poses various threats to marine life, particularly in shallow tropical waters.
Objective: The impact of increased temperature and ultraviolet (UV) exposure on two photosymbiotic cnidarians, a common bubble-tip anemone and an upside-down jellyfish, was investigated.
Methods: To illustrate the response of aquatic organisms, the metabolomes of unstressed Entacmaea quadricolor and Cassiopea andromeda were compared for detailed metabolite profiling.
Article Synopsis
- Climate change is causing problems for sea creatures like sea anemones and upside-down jellyfish, mainly from warmer oceans and harmful sunlight.
- Scientists studied how these animals react when exposed to heat and UV light, finding they change their body chemistry.
- They found different chemicals in jellyfish and sea anemones, showing that heat increases amino acids in jellyfish and both amino acids and sugars in sea anemones after a few days of UV exposure.
Trade-off between photosymbiosis and innate immunity influences cnidarian's response to pathogenic bacteria.
Proc Biol Sci
October 2024
Department of Biology, University of Texas at Arlington, Arlington, TX 76019, USA.
Article Synopsis
- Cnidarians, like jellyfish, often have a mutualistic relationship with photosynthetic dinoflagellates, which helps them gain nutrients but may weaken their immune response.
- Research focused on upside-down jellyfish revealed that symbiotic polyps had lower survival rates when exposed to pathogens compared to those without symbionts.
- Gene studies suggest that the immune responses of symbiotic polyps were more damaging, as they showed higher inflammation and stress levels, indicating a trade-off between nutrition from symbionts and their ability to defend against diseases.
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