AI Article Synopsis
- Lymphoma in horses has a poorly understood prognosis and is often treated palliatively; this study aimed to evaluate long-term outcomes of chemotherapy in affected horses.
- Out of 15 horses treated, 33.3% achieved complete remission and 60% had a partial response, resulting in a high overall response rate of 93.3%.
- Although the median survival was 8 months, many horses experienced mild to moderate adverse effects related to chemotherapy, with severe reactions linked to doxorubicin treatment.
Article Abstract
Background: Prognosis associated with lymphoma in horses is poorly characterized, and treatment is often palliative. Long-term outcome after chemotherapy for horses with lymphoma is not well documented.
Objective: To report long-term outcome of horses with lymphoma treated with chemotherapy.
Animals: Fifteen equids.
Methods: Retrospective case series. Medical record search and call for cases on the ACVIM listserv for horses treated with chemotherapy for lymphoma.
Results: Fifteen cases with adequate data were identified. Complete remission was achieved in 5 horses (33.3%), partial response was achieved in 9 equids (60%), and stable disease was achieved in 1 horse. Overall response rate was 93.3% (14/15). Overall median survival time was 8 months (range, 1-46 months). Nine horses experienced a total of 14 adverse effects attributable to chemotherapy. Adverse effects were graded according to the Veterinary Cooperative Oncology Group common terminology criteria for adverse events grading system (grade 1 alopecia, n = 2; grade 1 neutropenia, n = 2; grade 1 lymphopenia, n = 3; grade 1 lethargy, n = 1; grade 2 neurotoxicity, n = 1; grade 2 colic, n = 1; grade 1 hypersensitivity, n = 1; grade 2 hypersensitivity, n = 2; grade 5 hypersensitivity, n = 1). Higher grade adverse effects most commonly were associated with doxorubicin administration (n = 4), including 1 horse that died 18 hours post-administration.
Conclusions And Clinical Importance: Chemotherapy can be used successfully for treatment of horses with lymphoma. Adverse effects, most commonly mild, occurred in approximately two-thirds of treated horses.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430950 | PMC |
| http://dx.doi.org/10.1111/jvim.15411 | DOI Listing |
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