Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/s41436-018-0422-9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Long-Term Efficacy and Tolerability of an Emollient Containing Glycerol and Paraffin for Moderate-to-Severe Uremic Xerosis: A Randomized Phase 3 Study.
Dermatol Ther (Heidelb)
November 2024
Department of Dermatovenereology, Charles University Third Faculty of Medicine, and Kralovske Vinohrady University Hospital, Prague, Czech Republic.
Article Synopsis
- - The study tested the long-term effectiveness and safety of a topical emollient (V0034CR) for treating uremic xerosis and chronic kidney disease-related itching, comparing it to a vehicle control in a phase 3 trial.
- - Over 28 days, patients applying V0034CR showed a significant improvement in xerosis severity and a greater reduction in scaling compared to those using the control, with 60.2% of the V0034CR group responding positively.
- - While xerosis symptoms returned without treatment after a break, V0034CR helped maintain remission over a longer period, with high patient satisfaction and minimal side effects like minor irritation.
Ecological network analysis of traits reveals variable response capacity to stress.
Proc Biol Sci
May 2023
University of Auckland, Auckland, New Zealand.
Response diversity increases the potential 'options' for ecological communities to respond to stress (i.e. response capacity).
View Article and Find Full Text PDFBridging pre-surgical endocrine therapy for breast cancer during the COVID-19 pandemic: outcomes from the B-MaP-C study.
Breast Cancer Res Treat
June 2023
Cancer Sciences Academic Unit, University of Southampton and University Hospital Southampton, Tremona Road, Southampton, SO16 6YD, UK.
Purpose: The B-MaP-C study investigated changes to breast cancer care that were necessitated by the COVID-19 pandemic. Here we present a follow-up analysis of those patients commenced on bridging endocrine therapy (BrET), whilst they were awaiting surgery due to reprioritisation of resources.
Methods: This multicentre, multinational cohort study recruited 6045 patients from the UK, Spain and Portugal during the peak pandemic period (Feb-July 2020).
Thiol-Ene Photo-Click Hydrogels with Tunable Mechanical Properties Resulting from the Exposure of Different -Ene Moieties through a Green Chemistry.
Materials (Basel)
February 2023
Department of Mechanical and Aerospace Engineering, Politecnico di Torino, 10129 Turin, Italy.
Temperature and light responsiveness are widely exploited stimuli to tune the physico-chemical properties of double network hydrogels. In this work, new amphiphilic poly(ether urethane)s bearing photo-sensitive moieties (i.e.
View Article and Find Full Text PDFABCB1 Gene Variants and Antidepressant Treatment Outcomes: A Systematic Review and Meta-Analysis Including Results from the CAN-BIND-1 Study.
Clin Pharmacol Ther
July 2023
Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
The P-glycoprotein efflux pump, encoded by the ABCB1 gene, has been shown to alter concentrations of various antidepressants in the brain. In this study, we conducted a systematic review and meta-analysis to investigate the association between six ABCB1 single-nucleotide polymorphisms (SNPs; rs1045642, rs2032582, rs1128503, rs2032583, rs2235015, and rs2235040) and antidepressant treatment outcomes in individuals with major depressive disorder (MDD), including new data from the Canadian Biomarker and Integration Network for Depression (CAN-BIND-1) cohort. For the CAN-BIND-1 sample, we applied regression models to investigate the association between ABCB1 SNPs and antidepressant treatment response, remission, tolerability, and antidepressant serum levels.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!