[Long Program Intervention of Huluan Decoction on In Vitro Fertilization and Embryo Transfer].

Objective: To observe the curative effect and feasibility of Huluan Decoction (HD) in assisted reproductive technique (ART) for in vitro fertilization and embryo transfer (IVF-ET) patients.

Methods: Totally 120 patients were assigned to the Western medicine (WM) group (60 cases, as the control) and the WM + HD group (60 cases, as the intervention) according to random digit table. Patients in the control group received routine long-acting long program. Those in the intervention group additionally took HD, one dose per day for 12 successive days starting from the 3rd day of the menstrual cycle. The following indicators were observed in the two groups: endometrial thickness on human chorionic gonado- tropin (HCG) day, endometrial morphology, endometrial blood flow Applebaum type, spiral arteries blood flow pulsation index (PI) and resistance index (RI), gonadotropin (Gn) days, Gn dosage, the number of retrieval eggs, the rate of high quality eggs, the fertilization rate, the cleavage rate, the high quality embryo rate, the biochemical pregnancy rate, curative effect and integral of Shen deficiency syn- drome. And their effects on final pregnancy rate and liveborn birth rate were also observed.

Results: In the intervention group the number of retrieval eggs, the rate of high quality eggs, the fertilization rate, and the high quality embryo rate all increased (P <0. 05), endometrial thickness on HCG day significantly increased, PI and RI obviously decreased (P <0.01) , Gn days, Gn dosage, integral of Shen deficiency syndrome were reduced (P <0. 05), clinical pregnancy rate and liveborn birth rate were also elevated (P <0. 05) , as compared with the control group. Endometrial blood flow Applebaum type was superior in the intervention group to that in the control group (P <0. 05). The total effective rate was 96. 5% (55/57 cases) in the intervention group, higher than that in the control group [80. 0% (44/55 cases) ; P <0. 051.

Conclusion: In IVF-ET treatment cycle, use of HD could obviously improve clinical symptoms of Shen deficiency patients, elevate the quality of eggs and embryos, improve the endometrial receptivity, and fi- nally elevate clinical pregnancy rate and liveborn birth rate.