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Rational design of a triple-type HPV53/56/66 vaccine with one preferable base particle incorporating two identified immunodominant sites.
J Nanobiotechnology
January 2025
State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Discipline of Intelligent Instrument and Equipment, Department of Experimental Medicine, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, China.
The numerous high-risk carcinogenic types of human papillomavirus (HR-HPV) that lack vaccine protection underscore the urgent need to develop broader-spectrum HPV vaccines. This study addresses this need by focusing on HR-HPV types 53, 56, and 66, which are not currently targeted by existing vaccines. It introduces an effective method for their soluble expression, as well as that of their mutants, within an Escherichia coli expression system.
View Article and Find Full Text PDFThe treatment of acute traumatic aortic injuries with TEVAR: a retrospective analysis of 19 cases in a level-1 trauma center.
Langenbecks Arch Surg
January 2025
Department of Trauma Surgery, University Hospital Zurich, Rämistrasse 100, CH - 8091, Zurich, Switzerland.
Introduction: Blunt traumatic aortic injury (TAI) is a critical condition and a leading cause of mortality in trauma patients, often resulting from high-speed accidents. Thoracic endovascular aortic repair (TEVAR) has developed into the preferred therapeutic approach due to its minimally invasive nature and promising outcomes. This study evaluates the safety and efficacy of TEVAR for managing TAI over a 10-year period at a Level-1 trauma center.
View Article and Find Full Text PDFPsychometric Examination of the Proposed Specifiers for Conduct Disorder Self-Report (PSCD) Among an Adult Community Sample From Brazil.
Int J Offender Ther Comp Criminol
January 2025
University of Alabama, Tuscaloosa, AL, USA.
The Proposed Specifiers for Conduct Disorder (PSCD) is a promising novel scale that measures psychopathic traits and includes an additional conduct disorder factor that taps the antisocial dimension of psychopathy. The current study sought to broaden the application of PSCD by examining the factor structure, convergent and discriminant validity, and connections to delinquency in a young adult sample ( = 450; = 31.91 years, = 13.
View Article and Find Full Text PDFOur knowledge of the psychosocial implications of skin conditions continues to broaden, as research identifies multiple psychological morbidities relating to psoriasis, eczema and acne. This includes findings of poor body image, as a result of the change in physical appearance to the skin. However, there is limited qualitative research in the UK that explores how young women with skin conditions experience unique psychosocial impacts, including body image issues.
View Article and Find Full Text PDFFeasibility and pilot study of Indonesia's first telehealth support program for gynecological cancer survivors undergoing chemotherapy.
Narra J
December 2024
Department of Maternity Nursing and Women Health, Faculty of Nursing, Universitas Indonesia, Depok, Indonesia.
Most Indonesian gynecological cancer survivors experience chemotherapy side effects on their physical and mental health as they face unmet needs of supportive care, which increases the likelihood of discontinuing treatment. Interventions in telehealth assist survivors in resolving these issues. The aim of this pilot study was to determine the feasibility of fighting distress, self-efficacy, health effects, and sexual (FoRSHE-X) interventions and evaluate their potential impact on distress level, side effects knowledge and management, self-efficacy, and sexual quality of life.
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