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Nanothermodynamics: There's Plenty of Room on the Inside.
Nanomaterials (Basel)
November 2024
Department of Physics, Arizona State University, Tempe, AZ 85287-1504, USA.
Nanothermodynamics provides the theoretical foundation for understanding stable distributions of statistically independent subsystems inside larger systems. In this review, it is emphasized that extending ideas from nanothermodynamics to simplistic models improves agreement with the measured properties of many materials. Examples include non-classical critical scaling near ferromagnetic transitions, thermal and dynamic behavior near liquid-glass transitions, and the 1/-like noise in metal films and qubits.
View Article and Find Full Text PDFMulti-omics analysis in mouse primary cortical neurons reveals complex positive and negative biological interactions between constituent compounds in Centella asiatica.
bioRxiv
November 2024
Department of Neurology, Oregon Health & Science University, Portland, OR.
Background: A water extract of the Ayurvedic plant (CAW) improves cognitive function in mouse models of aging and Alzheimer's disease, and affects dendritic arborization, mitochondrial activity and oxidative stress in mouse primary neurons. Triterpenes (TT) and caffeoylquinic acids (CQA) are constituents associated with these bioactivities of CAW although little is known about how interactions between these compounds contribute to the plant's therapeutic benefit.
Methods: Mouse primary cortical neurons were treated with CAW, or equivalent concentrations of four TT combined, eight CQA combined, or these twelve compounds combined (TTCQA).
A 72-year-old woman on sertraline and levothyroxine (Levoxyl) presented to clinic with progressive proximal > distal and left > right upper and lower extremity weakness. She had length-dependent paresthesias and sensory deficits. Aldolase was elevated but CK was normal.
View Article and Find Full Text PDFFunctional distinction in oncogenic Ras variant activity in Caenorhabditis elegans.
Dis Model Mech
August 2024
Department of Molecular Genetics, Ohio State University, 484 West 12th Avenue, Columbus, OH 43210, USA.
Ras genes are important oncogenes that are frequently mutated in cancer. Human oncogenic variants exhibit functional distinctions in terms of their representation in different cancer types, impact on cellular targets and sensitivity to pharmacological treatments. However, how these distinct variants influence and respond to the cellular networks in which they are embedded is poorly understood.
View Article and Find Full Text PDFRe-assessing thermal response of schistosomiasis transmission risk: Evidence for a higher thermal optimum than previously predicted.
PLoS Negl Trop Dis
June 2024
Department of Biology, Stanford University, Stanford, California, United States of America.
Article Synopsis
- The study investigates how temperature affects schistosomiasis, a disease caused by schistosome parasites and their host snails, particularly in sub-Saharan Africa where the disease is common.
- Previous models underestimated the effective temperature range for schistosomiasis transmission, prompting this research to analyze how temperature influences the parasites and snails involved.
- The findings indicate that optimal transmission temperatures are higher than previously thought, suggesting that climate change may increase schistosomiasis risk in regions currently suitable for the disease.
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