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Differential bioaccumulation and histopathological changes induced by iron oxide nanoparticles and ferric chloride in the neotropical snail Biomphalaria glabrata.
Chemosphere
January 2025
Laboratory of Environmental Biotechnology and Ecotoxicology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, Goiás, Brazil. Electronic address:
Iron oxide nanoparticles (IONPs) are prominent in nanomedicine, cosmetics, and environmental applications. However, their increasing production, use, and release into the environment raises concerns about their potential risks to aquatic life and human health. This study aimed to evaluate the bioaccumulation, as concentration of small, medium and large iron aggregates in the digestive tubules, histopathological changes, and inflammatory responses in the freshwater snail Biomphalaria glabrata following chronic exposure to gluconic-acid functionalized IONPs (GLA-IONPs) compared to their dissolved counterpart (FeCl).
View Article and Find Full Text PDFLighting Up and Identifying Metal-Binding Proteins in Cells.
JACS Au
December 2024
Department of Chemistry and HKU-CAS Joint Laboratory of Metallomics for Health and Environment, The University of Hong Kong, Pokfulam Road, Hong Kong, SAR, P.R. China.
Article Synopsis
- Metal ions are essential for life and play therapeutic roles, with proteins and enzymes regulating their balance, making metallomics and metalloproteomics important fields of research.
- Fluorescence-based metalloproteomics enables the visualization and identification of metal-binding proteins in living organisms, enhancing our understanding of metal functions in biology and medicine.
- The text discusses labeling methods, showcases examples of metalloproteomics applications, and calls for advancements in fluorescence probes and imaging techniques to further explore this intriguing area of study.
Mesoarchean Microbial Cd, Ba, and Ni Cycling: Evidence for Photosynthesis in Pongola Group Stromatolites through Novel Stable Isotopes and High-Resolution Trace Element Maps.
Astrobiology
December 2024
Department of Mineralogy, University of Hannover, Germany.
Nontraditional stable isotopes of bioactive metals emerged as novel proxies for reconstructing the biogeochemical cycling of metals, which serve as cofactors in major metabolic pathways. The fractionation of metal isotopes between ambient fluid and microorganisms is ultimately recorded in authigenic minerals, such as carbonates, which makes them potentially more reliable than standard biomarkers in organic matter. Stromatolitic carbonates are geochemical archives that allow for the study of the long-term interplay of the biosphere, atmosphere, and hydrosphere through deep time, with the unique potential to investigate early life environments and the evolution of the metallome.
View Article and Find Full Text PDFCellular targets of cytotoxic copper phenanthroline complexes: a multimodal imaging quantitative approach in single PC3 cells.
Metallomics
November 2024
Centro de Ciências e Tecnologias Nucleares, Departamento de Engenharia e Ciências Nucleares, Instituto Superior Técnico, Universidade de Lisboa, Estrada Nacional 10, 2695-066 Bobadela LRS, Portugal.
Metal complexes are emerging as promising alternatives to traditional platinum-based cancer treatments, offering reduced side effects. However, understanding their cellular uptake and distribution and quantifying their presence at the single cell level remains challenging. Advanced imaging techniques, including transmission electron microscopy, synchrotron radiation X-ray fluorescence, and energetic ion beam-based nuclear microscopy (scanning transmission ion microscopy, particle-induced X-ray emission, elastic backscattering spectrometry), allow detailed high-resolution visualization of structure and morphology, high sensitivity for elemental detection with quantification within single cells, and the construction of 3D models of metal distribution, positioning them as powerful tools for assessing the cellular uptake and compartmentalization of complexes.
View Article and Find Full Text PDFMagnitude and timescales of Ca isotope variability in human urine: implications for bone mass balance monitoring.
Metallomics
November 2024
The Isotoparium, Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125, United States.
Calcium (Ca) isotopes in blood/urine are emerging biomarkers of bone mineral balance (BMB) in the human body. While multiple studies have investigated Ca isotopes in patients suffering from diseases affecting BMB, comparatively little effort has been devoted to understanding the homeostasis of Ca isotopes in healthy individuals. Here, we report on a longitudinal study of the urine Ca isotope composition (δ44/42CaUrine) from 22 healthy participants (age 19-60) over timescales ranging from days to months.
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