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Microglia and Immune cells interactions in multiple sclerosis cognitive impairment: a postmortem study.
J Neuroinflammation
December 2024
Research Institute for Medicines (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal.
Multiple Sclerosis (MS), a neuroinflammatory disease of the central nervous system, is one of the commonest causes of non-traumatic disability among young adults. Impaired cognition arises as an impactful symptom affecting more than 50% of the patients and with substantial impact on social, economic, and individual wellbeing. Despite the lack of therapeutic strategies, many efforts have been made to understand the mechanisms behind cognitive impairment in MS patients.
View Article and Find Full Text PDFMeasured energy expenditure according to the phases of critical illness: A descriptive cohort study.
JPEN J Parenter Enteral Nutr
December 2024
Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Background: Indirect calorimetry is recommended for directing energy provision in the intensive care unit (ICU). However, limited reports exist of measured energy expenditure according to the phases of critical illness in large cohorts of patients during ICU admission. This study aimed to analyze measured energy expenditure overall in adult patients who were critically ill and across the different phases of critical illness.
View Article and Find Full Text PDFLongitudinal determinants of thriving in Puerto Rican climate crisis migrants on the U.S. mainland: A structural equation model.
Soc Sci Med
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Department of Kinesiology and Health Education, University of Texas at Austin, United States.
Climate-related disasters pose significant risks to mental health and well-being globally. Individuals from disaster-prone regions, such as Puerto Rico, are at even greater risk. The devastating effects of recurrent hurricanes, compounded with pre-existing structural disparities (e.
View Article and Find Full Text PDFBridging trauma and eating disorders: the role of loneliness.
Front Psychiatry
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Eating Disorder Unit, Casa di Cura "Villa Margherita" - KOS Group, Vicenza, Italy.
Introduction: Eating disorders (EDs) are complex and often linked to traumatic childhood experiences. While childhood trauma is known to increase the risk of EDs, the role of loneliness remains underexplored. This study investigates whether loneliness mediates the relationship between childhood trauma and ED symptoms.
View Article and Find Full Text PDFIndirectly acquired fear memories have distinct, sex-specific molecular signatures from directly acquired fear memories.
PLoS One
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Translational Biology, Medicine and Health Graduate Program, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America.
Post-traumatic stress disorder (PTSD) is a severe anxiety disorder that affects women more than men. About 30% of patients suffering from PTSD develop the disorder by witnessing a traumatic event happen to someone else. However, as the focus has remained on those directly experiencing the traumatic event, whether indirectly acquired fear memories that underlie PTSD have the same molecular signature as those that are directly acquired remains unknown.
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