FoxP3 CXCR5 CD4 T cell frequencies are increased in peripheral blood of patients with primary Sjögren's syndrome.

Clin Exp Immunol

Division of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Published: March 2019

We recently explored the expression of CXCR5 on T and B cells from peripheral blood of patients with primary Sjögren's syndrome (SS). Here we investigated the frequency of CD25 FoxP3 CD4 regulatory T cells (T ) among CXCR5 CD4 follicular cells in the same cohort of patients. We confirm that the frequency of T among follicular T cells is increased in SS patients and also provide novel data showing an increased frequency of PD-1 expressing cells among CXCR5 FoxP3 CD4 T cells.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378374PMC
http://dx.doi.org/10.1111/cei.13244DOI Listing

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