AI Article Synopsis
- The American Urological Association recommended a single high-dose gentamicin prophylaxis (5 mg/kg) in 2008 for urologic procedures due to its theoretical safety and effectiveness.
- However, there's a lack of evidence-based studies confirming the safety of this practice specifically in penile prosthetic surgery.
- The text presents three cases where patients experienced acute kidney injury after receiving weight-based gentamicin prophylaxis during inflatable penile prosthesis implantation, highlighting potential safety concerns.
Article Abstract
Despite the known nephrotoxicity of gentamicin, in 2008 the American Urological Association published guidelines recommending single high-dose weight-based gentamicin prophylaxis of 5 mg/kg for procedures involving urologic prostheses. These guidelines are based on the theoretical renal safety and improved antimicrobial activity of a single large dose of gentamicin. However, the risk of nephrotoxicity after weight-based gentamicin prophylaxis specifically in penile prosthetic surgery has never been established with evidence-based studies. This is of special concern in light of the known high rates of preexisting conditions in this specific population. Therefore, in order to expose potential safety issues, we present three cases of postoperative acute kidney injury following weight-based gentamicin prophylaxis after implantation of inflatable penile prostheses.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304645 | PMC |
| http://dx.doi.org/10.1155/2018/3479202 | DOI Listing |
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Article Synopsis
- The American Urological Association recommended a single high-dose gentamicin prophylaxis (5 mg/kg) in 2008 for urologic procedures due to its theoretical safety and effectiveness.
- However, there's a lack of evidence-based studies confirming the safety of this practice specifically in penile prosthetic surgery.
- The text presents three cases where patients experienced acute kidney injury after receiving weight-based gentamicin prophylaxis during inflatable penile prosthesis implantation, highlighting potential safety concerns.
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