Effects of Percutaneous Kyphoplasty on Bone Metabolism and Oxidative Stress in Elderly Patients with Osteoporotic Spinal Fractures.

Objective: To investigate the effects of percutaneous kyphoplasty on bone metabolism and oxidative stress in elderly patients with osteoporotic spinal fractures.

Study Design: An experimental study.

Place And Duration Of Study: Department of Orthopedics, ZhangYe People's Hospital Affiliated to HeXi University, from February 2016 to October 2017.

Methodology: A total of 100 elderly patients with osteoporotic spinal fractures were randomly divided into the observation group treated with percutaneous kyphoplasty (PKP) and the control group treated with percutaneous vertebroplasty (PVP), with 50 cases in each group. One month after surgery, the content of serum bone metabolic markers bone gla protein (BGP), carboxyl-terminal collagen I crosslinks (- β), bone alkaline phosphatase (BALP) and tartrate-resistant acid phosphatase (TRACP), oxidative stress markers malondialdehyde (MDA), total antioxidant capacity (TAC) and superoxide dismutase (SOD) were compared between the two groups. Visual analogue scale (VAS) and the Oswestry Disability Index (ODI) were used to evaluate the degree of pain and functional status of the two groups, and the Cobb angles were measured in both groups.

Results: One month after surgery, the level of the serum bone metabolic marker BGP in the observation group was higher than the control group (p<0.001), and the levels of -CTX, BALP and TRACP in the observation group were lower than the control group (all p<0.001). The level of the serum oxidative stress marker MDA in the observation group was lower than the control group (p<0.001), and the levels of TAC and SOD in the observation group were higher than the control group (all p<0.001). There were no significant differences in VAS scores and ODI values between the two groups (p=0.806 and 0.913, respectively). Cobb's angle of the injured vertebrae in the observation group was smaller than the control group (p<0.001).

Conclusion: Compared with PVP, PKP is more effective in treating elderly patients with osteoporotic spinal fractures. It can effectively optimise bone metabolism, promote fracture healing, and reduce the oxidative stress reactions after surgery, with a relatively larger application value.