AI Article Synopsis
- Coreopsis tinctoria, a herbal medicine used in Xinjiang, China, shows potential in treating diabetic nephropathy through its extracts, particularly ethyl acetate (AC) and the compound marein.
- An experimental study on rat mesangial cells demonstrated that AC and marein prevented cell hyperplasia and reduced the levels of proteins associated with fibrosis and inflammation when exposed to high glucose conditions.
- The protective effects of AC and marein were linked to the regulation of key signaling pathways (TGF-β1/Smads, AMPK, NF-κB), suggesting their potential in slowing down renal damage in diabetes.
Article Abstract
Background: Coreopsis tinctoria Nutt is an ethnomedicine widely used in Xinjiang, China. It is consumed as a herbal tea by local Uyghur people to treat high blood pressure and diarrhea. Our previous study confirmed that the ethyl acetate extract of Coreopsis tinctoria (AC) had a protective effect on diabetic nephropathy (DN) in an in vivo experiment. Here we aim to elucidate the protective mechanism of AC and marein, the main ingredient in Coreopsis tinctoria on renal fibrosis and inflammation in vitro under high glucose (HG) conditions.
Methods: A HG-induced barrier dysfunction model in rat mesangial cells (HBZY-1) was established. The cells were exposed to AC and marein and/or HG for 24 h. Then, the renal protective effects of AC and marein via transforming growth factor-β1 (TGF-β1)/Smads, AMP-activated kinase protein (AMPK), and nuclear factor kappa beta (NF-κB) signaling were assessed.
Results: Both AC and marein suppressed rat mesangial cell hyperplasia and significantly attenuated the expression of HG-disrupted fibrotic and inflammatory proteins in HBZY-1 cells. It was also confirmed that AC and marein remarkably attenuated HG-induced renal inflammation and fibrosis by regulating the AMPK, TGF-β1/Smads, and NF-κB signaling pathways.
Conclusion: These results indicated that AC and marein may delay the progression of DN, at least in part, by suppressing HG-induced renal inflammation and fibrosis. Marein may be one of the bioactive compounds in AC.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327481 | PMC |
| http://dx.doi.org/10.1186/s12906-018-2410-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Extraction methods, structural features and bioactivity diversity of polysaccharides from the genus Chrysanthemum: A review.
Int J Biol Macromol
January 2025
Department of Pharmacy, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, 637000, P. R. China; School of Pharmacy, North Sichuan Medical College, Nanchong, Sichuan, 637000, P. R. China. Electronic address:
The genus Chrysanthemum has been widely used as both folk medicine and food in East Asia for thousands of years, serving as a significant source of nutritional and pharmacological value. According to the theory of traditional Chinese medicine, it clears heat and toxic materials and regulates liver function. Accumulating evidence has demonstrated that polysaccharides from the genus Chrysanthemum, especially Chrysanthemum morifolium, Chrysanthemum indicum, and Coreopsis tinctoria, are vital representative macromolecules with diverse biological activities, including antioxidant, immunomodulatory, anti-inflammatory, hypoglycemic, antitumor, and antiviral properties as well as the ability to regulate the gut microbiota.
View Article and Find Full Text PDFMarein ameliorates the progression of osteoarthritis: An in vitro and in vivo studies.
Int Immunopharmacol
January 2025
Department of Sports Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang 310000, China; Center for Rehabilitation Medicine, Department of Orthopedics, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang 310000, China; Institute of Sports Medicine and Osteoarthropathy of Hangzhou Medical College, Hangzhou, Zhejiang 310000, China. Electronic address:
Osteoarthritis (OA) is a prevalent, degenerative joint disease that requires effective treatments to prevent its progression. Therefore, the development of novel therapeutic strategies to address this unmet clinical challenge is paramount. Marein (MA), the principal active compound of Coreopsis tinctoria Nutt, exhibits anti-inflammatory and anti-oxidant properties in various diseases, indicating its potential as a therapeutic agent for OA.
View Article and Find Full Text PDFInhibition of coreopsin against α-amylase/α-glucosidase and synergy with acarbose.
Food Chem
February 2025
The College of Chemistry, Changchun Normal University, Changchun 130032, China. Electronic address:
Coreopsin is a flavonoid from Coreopsis tinctoria. The inhibition of coreopsin and synergy with acarbose against α-amylase (PPA) or α-glucosidase (SCG) were explored. As a result, coreopsin exhibited stronger inhibition on PPA/SCG than that of acarbose.
View Article and Find Full Text PDFGradient ethanol extracts of Coreopsis tinctoria buds: Chemical and in vitro fermentation characteristics.
Food Chem
February 2025
College of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, Guangdong Provincial Engineering Technology Research Center of Prefabricated Seafood Processing and Quality Control, Zhanjiang 524088, China; School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China. Electronic address:
Coreopsis tinctoria buds grow at high altitudes and have unique medicinal and health effects. This study focused on the chemical components of gradient ethanol extracts of Coreopsis tinctoria buds and their impact on the gut microbiota and its metabolites. UPLC-Q-Exactive-MS results disclosed the presence of 24 distinct chemicals in the extracts, marein, and quercetin-3-β-D-glucoside as the predominant antioxidants.
View Article and Find Full Text PDFExtraction, pharmacological prediction and experimental verification of flowers.
Nat Prod Res
October 2024
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China.
() is a traditional plant with high medicinal value and edible value. It has the effect of invigorating spleen and stomach and has the potential to develop into flower tea. Therefore, the extraction process of extract (CTA) was optimised by analytic hierarchy process (AHP) combined with orthogonal test, and its activity was predicted by network pharmacology and verified by experiments.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!