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Emergence of West Nile virus infection in Kerala, South India: A case of concern.
J Vector Borne Dis
January 2025
ICMR-Vector Control Research Centre Field Station, Kottayam, Kerala, India.
West Nile virus (WNV) infection is emerging as a disease of public health concern in Kerala, India with recurring outbreaks since 2011. With its tropical climate, biodiversity hot spots of Western ghats, forest cover, plenty of water bodies and bird sanctuaries, Kerala provides an ideal ecological niche for vector breeding and transmission of WNV. In this article, we reflect on the peculiar features of the outbreaks of WNV fever in Kerala and highlight the knowledge gaps, the research priorities and the need for effective control measures.
View Article and Find Full Text PDFWest Nile Fever- a looming risk and a call for effective response.
J Vector Borne Dis
January 2025
Department of Microbiology, Dr D Y Patil Medical College, Hospital &Research Center, Dr D Y Patil Vidyapeeth, Pimpri, Pune, India.
West Nile Virus (WNV) is an arboviral single-stranded RNA virus belonging to the Flaviviridae family. Initial reports of the virus were found in 1937 when the WNV was isolated from a febrile individual from Uganda and later reported from Algeria, West Africa, and the Middle East. Since then, every year cases of WNV infections are emerging and posing a threat to public health.
View Article and Find Full Text PDFBilateral facial nerve palsy in a patient with West Nile neuroinvasive disease.
J Infect Dev Ctries
December 2024
University Clinic for Infectious and Tropical Diseases of the University Clinical Centre of Serbia, Belgrade, Serbia.
Introduction: Bilateral facial nerve palsy (FNP) is a rare condition that is idiopathic in only 20%. FNP is the most common cranial neuropathy in West Nile neuroinvasive disease (WNND) but is usually unilateral and only a few cases of bilateral FNP have been reported.
Case: We present a case of a 65-year-old woman with confirmed WNND and simultaneous bilateral FNP.
West Nile Virus Encephalitis in a Patient with Chronic Lymphocytic Leukemia.
Mediterr J Hematol Infect Dis
January 2025
Infectious Disease Unit; "San Luca" Hospital, Vallo della Lucania, Italy.
Post-translational modifications play crucial roles in viral infections, yet many potential modifications remain unexplored in orthoflavivirus biology. Here we demonstrate that the UFMylation system, a post-translational modification system that catalyzes the transfer of UFM1 onto proteins, promotes infection by multiple orthoflaviviruses including dengue virus, Zika virus, West Nile virus, and yellow fever virus. We found that depletion of the UFMylation E3 ligase complex proteins UFL1 and UFBP1, as well as other UFMylation machinery components (UBA5, UFC1, and UFM1), significantly reduces infectious virion production for orthoflaviviruses but not the hepacivirus, hepatitis C.
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