AI Article Synopsis
- Recent studies emphasize the biological benefits of tocotrienols, a type of vitamin E, but purifying them from natural sources is challenging.
- The study presents effective semi-synthetic methods to create important δ-(R)-tocotrienol derivatives.
- These methods start with δ-(R)-garcinoic acid, which is derived from Garcinia kola nuts, a sustainable plant source.
Article Abstract
Recent studies have highlighted the biological potential of tocotrienols, a vitamin E subfamily. The major natural sources of tocotrienols are complex mixtures requiring particularly challenging purification processes. The present study describes efficient semi-synthetic strategies toward relevant δ-( R)-tocotrienol derivatives, using as a starting material δ-( R)-garcinoic acid, the major vitamin E derivative isolated from Garcinia kola nuts, a renewable vegetal source.
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| http://dx.doi.org/10.1021/acs.jnatprod.8b00517 | DOI Listing |
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