AI Article Synopsis
- The study aimed to analyze how CD80 expression in gastric adenocarcinoma correlates with prognosis and its relationship with immune cells.
- Researchers used techniques like PCR and immunohistochemistry to compare CD80 levels in cancerous and normal tissues, finding that CD80 was significantly downregulated in tumors.
- The results indicated that lower levels of CD80 are linked to poor outcomes for patients, making it a potential independent prognostic marker in gastric cancer.
Article Abstract
Aim: To study the expression and prognostic significance of CD80 in patients with gastric adenocarcinoma. Materials & methods: Real-time quantitative PCR, western blot and immunohistochemistry were performed to detect the expression of CD80 in gastric cancer tissues and matched adjacent normal tissues. Double immunohistochemical staining was performed to preliminary examine the relationship between CD80 cells and CD8 cytotoxic T lymphocytes.
Results: The expression of CD80 was downregulated in tumor tissues compared with normal tissues (p = 0.002). Immunohistochemistry analysis showed that 49 (39.8%) of 123 patients with gastric cancer demonstrated reduced CD80 expression, which was correlated with the tumor differentiation grade.
Conclusion: Our data suggest that reduced CD80 expression independently predicts a poor prognosis in patients with gastric adenocarcinoma.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2217/fon-2018-0420 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!