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Amidine synthesis by amine addition to nitriles normally requires high temperatures or harsh catalysts. Here, we report that boronate esters can facilitate amidination of proximal amines with moderate heating. With amidines present in a number of drugs and the synthetic handle provided by the boron, this chemistry should find useful applications.
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| http://dx.doi.org/10.1039/c8ob02696c | DOI Listing |
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Facile amidinations of 2-aminophenylboronic acid promoted by boronate ester formation.
Org Biomol Chem
January 2019
Institute for Glycomics, Gold Coast Campus, Griffith University, QLD 4222, Australia.
Amidine synthesis by amine addition to nitriles normally requires high temperatures or harsh catalysts. Here, we report that boronate esters can facilitate amidination of proximal amines with moderate heating. With amidines present in a number of drugs and the synthetic handle provided by the boron, this chemistry should find useful applications.
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