AI Article Synopsis
- * Sevoflurane is generally thought to have low potential for causing liver problems due to its metabolism process.
- * However, a case is reported where a 67-year-old woman experienced acute liver dysfunction following anesthesia with sevoflurane, indicating that it may still pose risks in certain circumstances.
Article Abstract
Halothane, isoflurane and desflurane are metabolized to hepatotoxic trifluoroacetyl proteins. But sevoflurane is metabolized to hexafluoroisopropanol. Hexafluoroisopropanol has a low binding affinity for liver protein and is therefore rapidly converted to glucuronidate that are excreted in the urine. Thus sevoflurane has been considered to have a very low potential for hepatotoxicity. We report a case of a 67 years old woman who developed acute hepatic dysfunction after sevoflurane anesthesia.
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| http://dx.doi.org/10.4097/kjae.2009.57.2.221 | DOI Listing |
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