AI Article Synopsis
- Oval cells are hepatic progenitor cells that activate to become hepatocytes during severe liver injury, often amidst inflammation.
- The study used TNFα to simulate inflammation and tested how matrilin-2 protects oval cells from cell death.
- Results indicated that matrilin-2 prevents apoptosis in oval cells by inhibiting a specific signaling pathway, highlighting its importance for oval cell survival and proliferation in injury contexts.
Article Abstract
Oval cells, a kind of hepatic progenitor cell quiescent at normal condition, activates to proliferate and differentiate into hepatocytes under severe and long-term liver injury, which usually raises severe inflammation. However, how oval cell survives in the inflammatory milieu interne is still unclear. Tumor necrosis factor α (TNFα), mimicking inflammatory hepatic milieu interne, was used to treat oval cell line, WB-F344, to test the protective function of matrilin-2. In this study, our data suggested that matrilin-2 prevented TNFα-induced apoptosis in WB-F344 cells via inhibiting ASK1/MKK7/JNK pathway. In conclusion, we determined that matrilin-2 plays the key role in maintaining the survival of oval cell and guarantees its proliferation under various injury factors.
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| http://dx.doi.org/10.1002/bab.1726 | DOI Listing |
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