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| http://dx.doi.org/10.1093/advances/nmy066 | DOI Listing |
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Dietary supplementation and the role of phytochemicals against the Alzheimer's disease: Focus on polyphenolic compounds.
J Prev Alzheimers Dis
January 2025
Indian Scientific Education and Technology Foundation, Lucknow, 226002, India. Electronic address:
Alzheimer's disease is a complicated, multifaceted, neurodegenerative illness that places an increasing strain on healthcare systems. Due to increasing malfunction and death of nerve cells, the person suffering from Alzheimer's disease (AD) slowly and steadily loses their memories, cognitive functions and even their personality. Although medications may temporarily enhance memory, there are currently no permanent therapies that can halt or cure this irreversible neurodegenerative process.
View Article and Find Full Text PDFFood additives for the central nervous system, useful or harmful? An evidence-based review.
Nutr Neurosci
January 2025
Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Objectives: This review examines how food additives impact the central nervous system (CNS) focusing on the effects of sugars, artificial sweeteners, colorings, and preservatives.
Methods: A literature search of PubMed, Scopus, and Web of Science was conducted for studies published since 2010. Key search terms included, food additives, neurotoxicity, cognition, and behavior.
Curcumin reverses cognitive deficits through promoting neurogenesis and synapse plasticity via the upregulation of PSD95 and BDNF in mice.
Sci Rep
January 2025
Institute of Basic Theory for Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, No.16, Nanxiaojie, Dongzhimen, Dongcheng District, Beijing, 100700, China.
Following prolonged exposure to hypoxic conditions, for example, due to ascent to high altitude, aging or stroke, cognitive deficits can develop. The exact nature and genesis of hypoxia-induced cognitive deficits remain unresolved. Curcumin has been reported to stimulate neurogenesis and reduce neuronal degeneration.
View Article and Find Full Text PDFMechanisms and early efficacy data of caloric restriction and caloric restriction mimetics in neurodegenerative disease.
Neuroscience
January 2025
Department of Biosciences, Jamia Millia Islamia, New Delhi, 110025, India; Manipal Centre for Biotherapeutics Research, Manipal Academy of Higher Education, Karnataka, Manipal, 576 104, India. Electronic address:
Neurodegenerative disorders (NDDs) have been prevalent for more than a decade, and the number of individuals affected per year has increased exponentially. Among these NDDs, Alzheimer's disease, which causes extreme cognitive impairment, and Parkinson's disease, characterized by impairments in motor activity, are the most prevalent. While few treatments are available for clinical practice, they have minimal effects on reversing the neurodegeneration associated with these debilitating diseases.
View Article and Find Full Text PDFNeuroprotective Effect of Curcumin-Metavanadate in the Hippocampus of Aged Rats.
Synapse
January 2025
Institute of Physiology, Benemerita Autonomous University of Puebla, Puebla, Mexico.
Brain aging is a multifactorial process that includes a reduction in the biological and metabolic activity of individuals. Oxidative stress and inflammatory processes are characteristic of brain aging. Given the current problems, the need arises to implement new therapeutic approaches.
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