Background: It is believed that the Wnt pathway is one of the most important signaling involved in gastric carcinogenesis.
Aim: To analyze the protein expression of canonical and non-canonical Wnt pathways in gastric carcinoma.
Method: The immunohistochemistry was performed in 72 specimens of gastric carcinomas for evaluating the expression of Wnt-5a, FZD5, GSK3β, axin, CK1, ubiquitin, cyclin D1 and c-myc.
Results: There were significant differences for cytoplasm and nucleus ubiquitin for moderately and well differentiated tumors (p=0.03) and for those of the intestinal type of the Lauren classification (p=0.03). The absence of c-myc was related to Lauren's intestinal tumors (p=0.03). Expression of CK1 in the cytoplasm was related to compromised margin (p=0.03). Expression of cyclin D1 protein was more intense in male patients (p=0.03) There was no relation of the positive or negative expression of the Wnt-5a, FZD5, GSK3 and Axin with any clinicopathological variables.
Conclusion: The canonical WNT pathway is involved in gastric carcinoma.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323632 | PMC |
| http://dx.doi.org/10.1590/0102-672020180001e1414 | DOI Listing |
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