The growing pandemia of AIDS, which resulted in about 40,000 AIDS patients and about 3 million infected persons by the end of 1986, demands for the urgent creation of methods for diagnosis, prevention and treatment of the disease. The present paper analyzes the main aspects of AIDS immunobiology, i. e. the molecular genetics of the virus, production of the viral components, construction of kits for immunoenzyme detection of antibodies to the virus, development of confirmatory immunoenzyme assays. The authors discuss the prospects of creating the synthetic antigens of the AIDS virus or producing them on the basis of genetic engineering both for the diagnosis and prophylaxis of the infection.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
V Brazilian Consensus on Rhinitis - 2024.
Braz J Otorhinolaryngol
September 2024
Universidade de São Paulo, São Paulo, SP, Brazil; Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial, São Paulo, SP, Brazil. Electronic address:
Article Synopsis
- The "V Brazilian Consensus on Rhinitis" is a significant update aimed at improving the understanding and management of rhinitis, focusing on evidence-based practices.
- * It includes detailed information on rhinitis phenotypes, diagnostic criteria, treatment customization based on symptoms and comorbidities, and the importance of thorough clinical evaluation.
- * The guideline also emphasizes patient education and addresses specific populations such as children, pregnant women, and the elderly to enhance overall quality of life for those affected by rhinitis.
Novel insights into the application of recombinant mutated phospholipases D as antigens for developing new strategies against Loxoscelism.
Acta Trop
October 2024
Department of Cell Biology, Federal University of Paraná (UFPR), Curitiba, 81530-900, PR, Brazil. Electronic address:
Loxoscelism is the pathological condition triggered by a brown spider bite. The venom of these spiders is rich in phospholipases D (PLDs), which can induce virtually all local and systemic manifestations. Recombinant mutated PLDs from clinically relevant Loxosceles species in South America have been investigated as potential antigens to develop novel therapeutic strategies for loxoscelism.
View Article and Find Full Text PDFMolecular and Structural Insights into Buffalo Interleukin-17A.
J Interferon Cytokine Res
May 2024
Department of Veterinary Microbiology and Lala Lajpat Rai University of Veterinary and Animal Sciences (LUVAS), Hisar, Haryana, India.
Interleukin-17A is a pro-inflammatory cytokine that plays a key role in the immune response to many pathogens and implicated in autoimmune diseases. This molecule is also involved in providing protection to many bacterial and fungal infections of gastro-intestinal tract and respiratory mucosa. Although molecular aspect of IL-17A has been studied in few species, no data are available for buffalo, which is one of the major sources of milk production in India.
View Article and Find Full Text PDFMain Aspects of Pharmaceutical Development of Immunobiological Drugs for Intranasal Administration.
Curr Pharm Biotechnol
July 2024
Institute of Pharmacy, Sechenov First Moscow State Medical University, Moscow, Russian Federation.
Introduction: The review presents the latest developments in the area of intranasal in situ delivery systems of immunobiological drugs (IBDs). Interest in intranasal administration for IBDs has increased significantly due to the COVID-19 pandemic. However, not only intranasal delivery of vaccines is developing, but also bacteriophages, interferons, etc.
View Article and Find Full Text PDFEmpagliflozin treatment of cardiotoxicity: A comprehensive review of clinical, immunobiological, neuroimmune, and therapeutic implications.
Biomed Pharmacother
December 2023
Clinical Research Development unit of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran; Department of Cardiology, Babol University of Medical Sciences, Babol, Iran. Electronic address:
Cancer and cardiovascular disorders are known as the two main leading causes of mortality worldwide. Cardiotoxicity is a critical and common adverse effect of cancer-related chemotherapy. Chemotherapy-induced cardiotoxicity has been associated with various cancer treatments, such as anthracyclines, immune checkpoint inhibitors, and kinase inhibitors.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!