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Establishment of Stable Knockdown of MACC1 Oncogene in Patient-Derived Ovarian Cancer Organoids.
Methods Protoc
December 2024
Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.
High-grade serous ovarian cancer (HGSOC) remains the most lethal gynecological malignancy, and there is still an unmet medical need to deepen basic research on its origins and mechanisms of progression. Patient-derived organoids of high-grade serous ovarian cancer (HGSOC-PDO) are a powerful model to study the complexity of ovarian cancer as they maintain, in vitro, the mutational profile and cellular architecture of the cancer tissue. Genetic modifications by lentiviral transduction allow novel insights into signaling pathways and the potential identification of biomarkers regarding the evolution of drug resistance.
View Article and Find Full Text PDFInnovative nanocarrier systems for enhanced delivery of phyto-active compounds in cancer therapy.
Nanomedicine (Lond)
December 2024
Department of Pharmaceutical Sciences, Shalom Institute of Health & Allied Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences, Allahabad, India.
Millions of people worldwide suffer from cancer, facing challenges such as treatments affecting healthy cells, suboptimal responses, adverse effects, recurrence risk, drug resistance, and nonspecific targeting. Chemoresistance leads to fatalities, but phytoactives show promise in cancer management despite limitations such as high metabolism, poor absorption, and high dosage requirements. Challenges in the large-scale isolation of phytoactive compounds, solubility, bioavailability, and targeting limit their development.
View Article and Find Full Text PDFIdentify unmet needs in diabetes care in Shandong, China: a secondary analysis of a cross-sectional study using cascade of care framework.
BMC Endocr Disord
December 2024
School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Background: The continuum management of diabetes remains under-evaluated in China. This study aimed to estimate the proportions of diabetes adults at each stage of the cascade of care framework in Shandong, China.
Methods: We conducted a secondary analysis using the 2018 China Adult Chronic Disease and Nutrition Surveillance (CACDNS) data in Shandong.
Glabridin exhibits potent inhibitory effects against Toxoplasma gondii in vitro and in vivo.
Parasit Vectors
December 2024
Laboratory of Parasitic Diseases, College of Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi Province, 030801, People's Republic of China.
Article Synopsis
- Toxoplasma gondii is a common parasite in warm-blooded animals and humans, with current treatments like pyrimethamine and sulfadiazine having significant limitations, prompting a search for safer, more effective options.
- This study focused on glabridin, a natural compound from a medicinal plant, finding it to be low in toxicity while effectively inhibiting T. gondii growth and altering its structure.
- The results showed that glabridin improved survival rates in infected mice and affected T. gondii's metabolism, suggesting a promising new treatment avenue for this parasite.
The epithelial era of asthma research: knowledge gaps and future direction for patient care.
Eur Respir Rev
October 2024
Center for Heart Lung Innovation, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
The Epithelial Science Expert Group convened on 18-19 October 2023, in Naples, Italy, to discuss the current understanding of the fundamental role of the airway epithelium in asthma and other respiratory diseases and to explore the future direction of patient care. This review summarises the key concepts and research questions that were raised. As an introduction to the epithelial era of research, the evolution of asthma management throughout the ages was discussed and the role of the epithelium as an immune-functioning organ was elucidated.
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