Synthesis and Spectroscopic Identification of Certain Imidazole-Semicarbazone Conjugates Bearing Benzodioxole Moieties: New Antifungal Agents.

During the last three decades the extent of life-threatening fungal infections has increased remarkably worldwide. Synthesis and structure elucidation of certain imidazole-semicarbazone conjugates ⁻ are reported. Single crystal X-ray analysis of compound unequivocally confirmed its assigned chemical structure and the ()-configuration of its imine double bond. Compound crystallized in the triclinic system, P-1, a = 6.3561 (3) Å, b = 12.5095 (8) Å, c = 14.5411 (9) Å, α = 67.073 (4)°, β = 79.989 (4)°, γ =84.370 (4)°, V = 1048.05 (11) ų, Z = 2. In addition, DIZ and MIC assays were used to examine the in vitro antifungal activity of the title conjugates ⁻ against four fungal strains. Compound , bearing a 4-ethoxyphenyl fragment, showed the best MIC value (0.304 µmol/mL) against both and species, while compounds (MIC = 0.311 µmol/mL), , and (MIC = 0.287 µmol/mL) exhibited the best anti- activity.