Six fungal metabolites, of which five were new, including one (1) with a dioxa[4.3.3]propellane ring system, were discovered, identified, and structurally elucidated from Neosetophoma sp. (strain MSX50044); these compounds are similar to the bis-tropolone, eupenifeldin. Three of the meroterpenoids are potent cytotoxic agents against breast, ovarian, mesothelioma, and lung cancer cells with nanomolar IC values while not inducing mitochondrial toxicity at 12.5 μM.
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| http://dx.doi.org/10.1021/acs.orglett.8b03769 | DOI Listing |
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Meroterpenoids from Neosetophoma sp.: A Dioxa[4.3.3]propellane Ring System, Potent Cytotoxicity, and Prolific Expression.
Org Lett
January 2019
Department of Chemistry and Biochemistry , University of North Carolina at Greensboro, Greensboro , North Carolina 27402 , United States.
Six fungal metabolites, of which five were new, including one (1) with a dioxa[4.3.3]propellane ring system, were discovered, identified, and structurally elucidated from Neosetophoma sp.
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