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New evidence for the earliest ornithischian dinosaurs from Asia.
iScience
January 2025
Center for Vertebrate Evolutionary Biology, Yunnan University, Kunming 650091, China.
The Early Jurassic ornithischian dinosaurs in Laurasia are dominated by armored dinosaurs, with other early ornithischian groups being rare. Here, a new taxon, gen. et sp.
View Article and Find Full Text PDFTransformative social innovation and rural collaborative workspaces: assembling community economies in Austria and Greece.
Open Res Eur
January 2025
Department of Economic and Regional Development,, Panteion University of Social and Political Sciences, Athens, L. Syggrou 136, 16761, Greece.
Background: Collaborative Workspaces are rapidly growing and evolving across the world. Traditionally understood as an urban phenomenon, most research understands them as either 'entrepreneurial-led', as profit-driven and commercial spaces such as business incubators and accelerators, or 'community-led' as being bottom-up, not-for-profit ventures aimed at catering for the needs of their community. Recent years however have seen their diffusion beyond large urban agglomerations to small towns and villages, with their functions assumed to be more community-orientated.
View Article and Find Full Text PDFA reproducible framework for monitoring the impact of randomized clinical trials on clinical practice using large-scale real-world data: application to gynaecological surgical trials using the French national healthcare database.
EClinicalMedicine
February 2025
Department of Breast and Gynaecological Surgery, Institut Curie, Paris, France.
Background: Randomized clinical trials (RCTs) are fundamental to evidence-based medicine, but their real-world impact on clinical practice often remains unmonitored. Leveraging large-scale real-world data can enable systematic monitoring of RCT effects. We aimed to develop a reproducible framework using real-world data to assess how major RCTs influence medical practice, using two pivotal surgical RCTs in gynaecologic oncology as an example-the LACC (Laparoscopic Approach to Cervical Cancer) and LION (Lymphadenectomy in Ovarian Neoplasms) trials.
View Article and Find Full Text PDFPerceptions of final-year medical students and interns toward pursuing a career in critical care medicine.
Front Med (Lausanne)
January 2025
College of Medicine, Jazan University, Jazan, Saudi Arabia.
Background: Critical care medicine (CCM) faces challenges in attracting new physicians due to its demanding nature. Understanding medical students' and interns' perceptions of CCM is essential to address physician shortages and improve medical training.
Objective: To evaluate the factors influencing specialty selection and explore perceptions of final-year medical students and interns toward CCM at Jazan University.
ScRNA-seq unveils the functional characteristics of glioma-associated macrophages and the regulatory effects of chlorogenic acid on the immune microenvironment-a study based on mouse models and clinical practice.
Front Immunol
January 2025
Department of Neuro-oncology, Cancer Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Introduction: Glioma is the most common primary malignant brain tumor. Despite advances in surgical techniques and treatment regimens, the therapeutic effects of glioma remain unsatisfactory. Immunotherapy has brought new hope to glioma patients, but its therapeutic outcomes are limited by the immunosuppressive nature of the tumor microenvironment (TME).
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