AI Article Synopsis
- The anti-inflammatory effects of hexane (TlH) and acetone (TlAc) extracts from certain plants were tested in mice that developed ear swelling due to TPA.
- Five coumarin compounds were identified in the TlH extract, including some that were previously unknown.
- One compound demonstrated the strongest anti-inflammatory action, reducing swelling by 81.1%, while others had lower effectiveness, emphasizing the importance of specific chemical structures in their activity.
Article Abstract
The anti-inflammatory activity of hexane (TlH) and acetone (TlAc) extracts from the aerial parts of were evaluated in a mice model of 12-Ο-Tetradecanoylphorbol 13-Acetate (TPA)-induced auricular oedema. Also, five coumarin compounds from the TlH extract were identified, characterized and evaluated: 7-isoprenyloxycoumarin (), herniarin (), 6-methoxy-7-isoprenyloxycoumarin (), 6,7,8-trimethoxycoumarin () and scoparone (). Compounds and had not been previously identified in . Compound showed the highest activity with an 81.1% of oedema inhibition, while reduced it in 54.4%, the other compounds showed less than 50% of inhibitory activity. The chemical structure of the compounds reveal that the substituent at the C-7 position is a crucial factor in exerting the anti-inflammatory activity.
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| http://dx.doi.org/10.1080/14786419.2018.1553172 | DOI Listing |
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