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Discovery of a Chimeric Polyketide Family as Cancer Immunogenic Chemotherapeutic Leads.
J Am Chem Soc
December 2024
Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States.
Discovery of cancer immunogenic chemotherapeutics represents an emerging, highly promising direction for cancer treatment that uses a chemical drug to achieve the efficacy of both chemotherapy and immunotherapy. Herein, we report a high-throughput screening platform and the subsequent discovery of a new class of cancer immunogenic chemotherapeutic leads. Our platform integrates informatics-based activity metabolomics for the rapid identification of microbial natural products with both novel structures and potent activities.
View Article and Find Full Text PDFIntroduction: Primary mucinous cystadenoma is a very rare lesion in the spleen, with only a few reported cases available in the literature. Ectopic pancreatic or enteric tissue and invaginated splenic capsular epithelium are assumed to be the origin of mucinous cystadenomas of the spleen. We present the first reported case in Ethiopia.
View Article and Find Full Text PDFLow grade appendiceal mucinous neoplasm mimicking malignant ovarian tumor: A case report.
Int J Surg Case Rep
December 2024
University of Gondar College of Medicine and Health Sciences, Ethiopia.
Introduction: Mucinous appendiceal neoplasms are unique tumors in which >50 % of the tumor volume is composed of extracellular mucin. They may present as an unruptured mucin-filled appendix or, more commonly, with peritoneal metastases after rupture or transmural invasion of the primary tumor. This case report describes a case of presumed ovarian malignancy with final pathologic diagnosis of low grade appendiceal mucinous neoplasm.
View Article and Find Full Text PDFPorcelain appendix: a rare mimicker of the acute abdomen.
BMJ Case Rep
December 2024
Department of Pathology, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
An appendiceal mucocele is a rare clinical entity often mimicking that of acute appendicitis in a majority of cases leading to incidental intraoperative findings. Nevertheless, appropriate diagnosis is vital prior to surgery to prevent complications such as pseudomyxoma peritonei. This report details a case of a man in his 70s, who was admitted to the emergency department with right iliac fossa pain with imaging showing wall thickening of the caecum and the ascending colon.
View Article and Find Full Text PDFA Rare Case of Low-Grade Appendiceal Mucinous Neoplasm Presenting As Mucinous Vaginal Discharge.
Cureus
November 2024
Obstetrics and Gynecology, Conway Medical Center, Myrtle Beach, USA.
Appendiceal mucinous neoplasms (AMNs) are rare tumors that often present with non-specific symptoms, posing diagnostic challenges. This report aims to emphasize the importance of considering AMNs in the differential diagnosis of atypical pelvic symptoms, especially when initial evaluations suggest gynecological issues. A 56-year-old female with a past medical history of hyperlipidemia and a total vaginal hysterectomy performed over 20 years prior for abnormal uterine bleeding due to fibroids presented to her gynecologist with a three-week history of vaginal discharge and pelvic pain.
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