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A bifunctional coumarin-based CD probe for chiral analysis of amino acids in aqueous solution.
Spectrochim Acta A Mol Biomol Spectrosc
December 2024
Department of Chemistry, University of Virginia, Charlottesville, VA 22904, United States. Electronic address:
Amino acids play important roles in human pathology and physiology and the qualitative and quantitative determination of chiral amino acids in humans and mammals also has important impacts on the life sciences. Therefore, the introduction of artificial probes to assess the concentrations and enantiomeric compositions [ee = ([D] - [L])/([D] + [L])] of amino acids in aqueous solution is necessary in understanding certain biological processes and diagnosing and treating diseases. Herein, a bifunctional achiral coumarin probe (Br-Coumarin) is reported to determine the absolute configuration, ee value, and concentration of 16 amino acids in THF/HO = 1/4 solution at micromolar concentrations.
View Article and Find Full Text PDFModeling the effect of daytime duration on the biosynthesis of terpenoid precursors.
Front Plant Sci
November 2024
Systems Biology Group, Department Ciències Mèdiques Bàsiques, Faculty of Medicine, Universitat de Lleida, Lleida, Spain.
Terpenoids are valued chemicals in the pharmaceutical, biotechnological, cosmetic, and biomedical industries. Biosynthesis of these chemicals relies on polymerization of Isopentenyl di-phosphate (IPP) and/or dimethylallyl diphosphate (DMAPP) monomers, which plants synthesize using a cytosolic mevalonic acid (MVA) pathway and a plastidic methyleritritol-4-phosphate (MEP) pathway. Circadian regulation affects MVA and MEP pathway activity at three levels: substrate availability, gene expression of pathway enzymes, and utilization of IPP and DMAPP for synthesizing complex terpenoids.
View Article and Find Full Text PDFHealth-Promoting Housing and Care Concepts for Older People with Dementia?
Stud Health Technol Inform
November 2024
SINTEF Community.
Norwegian municipalities require increasing the number of care places. The main challenge for the municipalities is to obtain enough high-quality and suitable residential facilities. As buildings are often inflexible structures, they will impact their daily lives for decades.
View Article and Find Full Text PDFEvaluating the Impact of a Daylight-Simulating Luminaire on Mood, Agitation, Rest-Activity Patterns, and Social Well-Being Parameters in a Care Home for People With Dementia: Cohort Study.
JMIR Mhealth Uhealth
November 2024
Chroma Lighting, Belfast, United Kingdom.
Background: Living with a diagnosis of dementia can involve managing certain behavioral and psychological symptoms. Alongside cognitive decline, this cohort expresses a suppression in melatonin production which can negatively influence their alignment of sleep or wake timings with the 24 hour day and night cycle. As a result, their circadian rhythms become disrupted.
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