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Efficiency of fixed-dose combinations of statin and ezetimibe in the treatment of hypercholesterolemia.
Clin Investig Arterioscler
January 2025
Unidad de Cardiología, Hospital Universitario de Jaén, Jaén, España.
Objective: To estimate the clinical and economic benefits derived from increasing the use of fixed-dose combinations of high-intensity statins and ezetimibe in patients at high/very high cardiovascular risk, from the perspective of the Spanish National Health System (SNS).
Methods: A baseline scenario (current market shares) was compared with scenarios that increased the use of fixed-dose combinations (alternative: 30% increase; optimized: 69% increase). The potential annual increase in the number of controlled patients, cardiovascular events avoided and the associated savings in direct medical costs were estimated, including the cost of pharmacological treatment, follow-up, and managing cardiovascular events over a three-year time horizon.
Determining the Efficacy of Chemicals for the Inactivation of Liquid Waste Containing Gram-Positive Bacteria of Risk Group 2.
Appl Biosaf
December 2024
Neuroinfection Laboratory Institute for Infectious Diseases, University of Bern, Bern, Switzerland.
Background: Inactivation of infectious liquid waste can be performed by different means, including autoclaving or chemical inactivation. Autoclaving is most widely used, but cannot always be implemented, so that chemical inactivation is a possible alternative. However, its efficacy has to be proven by in-house validation.
View Article and Find Full Text PDFSevere nephrotoxicity during high-dose methotrexate administration in an adolescent with acute lymphoblastic leukemia.
Arch Argent Pediatr
December 2024
Hospital de Pediatría S.A.M.I.C. Prof. Dr. Juan P. Garrahan, City of Buenos Aires, Argentina.
High-dose methotrexate is an effective and safe therapy. It is included in the treatment regimens of various hematologic and oncologic diseases. The acute and severe toxicity of this chemotherapeutic agent is unusual.
View Article and Find Full Text PDFOutcome and incidence of hypothyroidism in low-dose radioactive iodine treatment for hyperthyroidism.
Rev Esp Med Nucl Imagen Mol (Engl Ed)
September 2024
Department of Nuclear Medicine, Mackay Memorial Hospital, Taipei, Taiwan.
Objective: The study aimed to analyze the outcome of low-dose radioactive iodine (RAI) treatment for hyperthyroidism, disclose whether age and gender influence the outcome and determine the incidence and onset time of hypothyroidism following low-dose RAI.
Material And Methods: A total of 158 patients who received doses less than 370 Mbq RAI were enrolled in the study. Treatment outcome and incidence of hypothyroidism were compared between different gender (45 male vs.
[Silica exposure among miners at high altitude. Inhaled dose and evaluation methods in hypobaric environments].
Arch Prev Riesgos Labor
January 2024
Departamento de Medicina Física y Rehabilitación. Centro de Rehabilitación Integral Hospital San Camilo, San Felipe, Chile, Chile.
Objective: To evaluate silica exposure among Chilean miners at high altitude, using different methodological approaches, for the purpose of determining the safest method to control exposures. Methods: The 46 miners in the sample worked at 3000 meters above sea level in nonstandard work shifts, consisting of four consecutive 12-hour days, followed by four consecutive days off. Silica samples were obtained in each of the jobs positions of these 46 high-altitude miners.
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