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CircUCK2(2,3) promotes cancer progression and enhances synergistic cytotoxicity of lenvatinib with EGFR inhibitors via activating CNIH4-TGFα-EGFR signaling.
Cell Mol Biol Lett
January 2025
Clinical Research Center, Jiading District Central Hospital Affiliated to Shanghai University of Medicine and Health Sciences, Shanghai, 201800, China.
Background: Circular (circ)RNAs have emerged as crucial contributors to cancer progression. Nonetheless, the expression regulation, biological functions, and underlying mechanisms of circRNAs in mediating hepatocellular carcinoma (HCC) progression remain insufficiently elucidated.
Methods: We identified circUCK2(2,3) through circRNA sequencing, RT-PCR, and Sanger sequencing.
The microplastic menace: a critical review of its impact on marine photoautotrophs and their environment.
Environ Sci Pollut Res Int
January 2025
Applied Phycology and Biotechnology Department, CSIR- Central Salt and Marine Chemicals Research Institute, Gijubhai Badheka Marg, Bhavnagar, Gujarat, India, 364002.
Seaweeds contribute to the energy input in marine communities and affect the chemical makeup, species composition, nutrient availability, pH, and seawater oxygen levels. However, the annual introduction of 28.5 million tons of plastic waste into oceans makes up 85% of marine litter, which is expected to grow fourfold in the next 25 years, causing a rise in concern for human health and the environment.
View Article and Find Full Text PDFHigh glucose/ChREBP-induced Hif-1α transcriptional activation in CD4 T cells reduces the risk of diabetic kidney disease by inhibiting the Th1 response.
Diabetologia
January 2025
Kidney Transplantation Center, Department of Urology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Aims/hypothesis: Diabetic kidney disease (DKD) features intrarenal inflammation, in which T cells play a part. Hypoxia-inducible factor-1α (HIF-1α), a key transcription factor regulating cellular responses to hypoxia, is reportedly involved in the course of inflammation. The role of HIF-1α in DKD has been investigated, but the conclusions are controversial so far.
View Article and Find Full Text PDFVitamin D differentiates dopamine neurons in vitro, increasing neurite architecture, dopamine release and expression of relevant synaptic proteins.
J Steroid Biochem Mol Biol
January 2025
Queensland Brain Institute, University of Queensland, Qld 4072, Australia; Queensland Centre for Mental Health Research, Wacol, Qld 4076, Australia. Electronic address:
Epidemiological studies often link circulatory levels of 25 hydroxy vitamin D with an overwhelming variety of disorders. Of such studies, an increasing number are now linking blood 25 hydroxy vitamin D levels with certain brain disorders. Prominent amongst such disorders are schizophrenia and Parkinson's disease.
View Article and Find Full Text PDFNanoparticle-based Drug Delivery Systems to Modulate Tumor Immune Response for Glioblastoma Treatment.
Acta Biomater
January 2025
School of Materials and Energy, Southwest University, Chongqing 400715, China; Yibin Academy of Southwest University, Yibin 644005, China. Electronic address:
Glioblastoma (GBM) is a primary central nervous system neoplasm, characterized by a grim prognosis and low survival rates. This unfavorable therapeutic outcome is partially attributed to the inadequate immune infiltration and an immunosuppressive microenvironment, which compromises the effectiveness of conventional radiotherapy and chemotherapy. To this end, precise modulation of cellular dynamics in the immune system has emerged as a promising approach for therapeutic intervention.
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