A Rh-catalyzed enantioselective hydroamination of allylamines using a chiral BIPHEP-type ligand is reported. Enantioenriched 1,2-diamines are formed in good yields and with excellent enantioselectivities. A diverse array of nucleophiles and amine directing groups are demonstrated, including deprotectable motifs. Finally, the methodology was demonstrated toward the rapid synthesis of 2-methyl-moclobemide.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693864 | PMC |
| http://dx.doi.org/10.1021/jacs.8b09811 | DOI Listing |
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