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Stress and telomere length in leukocytes: Investigating the role of GABRA6 gene polymorphism and cortisol.

Psychoneuroendocrinology

January 2025

Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium. Electronic address:

Telomere length (TL) is considered a biomarker of aging, and short TL in leukocytes is related to age and stress-related health problems. Cumulative lifetime stress exposure has also been associated with shorter TL and age-related health problems, but the mechanisms are not well understood. We tested in 108 individuals whether shorter TL in leukocytes is observed in individuals with the GABRA6 TT genotype, which has been associated with dysregulation of hypothalamic-pituitary-adrenal axis activity (the main biological stress system) compared to the CC genotype.

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Psychological chronic pain treatments have variable efficacy across individual patients, and on average tend to produce modest effects. In order to improve treatment outcomes, the past decade has seen a rapid increase in research focused on determining the mechanisms underlying treatment-related gains. The near exclusive focus of this research has been on uncovering patient-related mediators and moderators.

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Background: Sarcoidosis, a granulomatous inflammatory disease, exhibits diverse clinical manifestations, often affecting multiple organs. Diagnostic challenges arise due to its similarities with tuberculosis, particularly in high-burden areas. Differentiating between the two relies on clinical judgment, laboratory tests, imaging, and invasive procedures.

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The Association of Psychological Factors With Willingness to Share Health-Related Data From Technological Devices: Cross-Sectional Questionnaire Study.

JMIR Form Res

January 2025

Department of Medical and Clinical Psychology, Center of Research on Psychological Disorders and Somatic Diseases (CoRPS), Tilburg University, Tilburg, the Netherlands, 31 134662142.

Background: Health-related data from technological devices are increasingly obtained through smartphone apps and wearable devices. These data could enable physicians and other care providers to monitor patients outside the clinic or assist individuals in improving lifestyle factors. However, the use of health technology data might be hampered by the reluctance of patients to share personal health technology data because of the privacy sensitivity of this information.

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Clinical Relevance: Although laser refractive surgeries and multifocal intraocular lens implantation are generally avoided in patients with diabetic retinopathy, a substantial proportion of well-glycaemic-controlled type 2 diabetes mellitus patients are considered for these procedures. Pupil dynamics play a significant role in determining postoperative satisfaction in these patients.

Background: To evaluate pupillary dynamics in patients with and without diabetes following uneventful phacoemulsification surgery.

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