This image series shows how bypass grafts may tent the vessel to which they are anastomosed, potentially changing the expected course of the native coronary vessel. This fact must be taken into account during CTO-PCI, and this case emphasizes the importance of careful analysis of coronary anatomy with several angiographic projections.
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Books: : An exploration of our inner world.
Br J Gen Pract
January 2025
Salaried GP in Derby. Email:
On the causal connection in lifespan correlations and the possible existence of a 'number of life' at molecular level.
Sci Rep
December 2024
Departamento de Astronomía, Universidad de Chile, Casilla 36-D, Santiago, Chile.
Multiple physiological traits correlates with lifespan, being unclear both the causal connection among them and with the process of ageing. In this paper, we show that six traits (such as metabolic rate, mass, heart rate, etc) acting at the system level, are all related to lifespan thru the existence of an approximately constant number of respiration cycles in a lifespan ([Formula: see text]), therefore, we find that those relationships are not independently related to ageing. In addition, we study if the approximately constant [Formula: see text] is possibly linked with the end-of-lifespan somatic mutation burden, another number recently found to be approximately constant (Cagan, Nature 604:517-524, 2022).
View Article and Find Full Text PDFAugmented prediction of vertebral collapse after osteoporotic vertebral compression fractures through parameter-efficient fine-tuning of biomedical foundation models.
Sci Rep
December 2024
Department of Medical Device Development, Seoul National University College of Medicine, Seoul, Republic of Korea.
Vertebral collapse (VC) following osteoporotic vertebral compression fracture (OVCF) often requires aggressive treatment, necessitating an accurate prediction for early intervention. This study aimed to develop a predictive model leveraging deep neural networks to predict VC progression after OVCF using magnetic resonance imaging (MRI) and clinical data. Among 245 enrolled patients with acute OVCF, data from 200 patients were used for the development dataset, and data from 45 patients were used for the test dataset.
View Article and Find Full Text PDFModeling predicts facile release of nitrite but not nitric oxide from the thionitrate CHSNO with relevance to nitroglycerin bioactivation.
Sci Rep
December 2024
Department of Chemistry and Biochemistry, Centre for Research in Molecular Modeling (CERMM), Concordia University, 7141 Sherbrooke Street West, Montréal, QC, H4B 1R6, Canada.
Nitroglycerin is a potent vasodilator in clinical use since the late 1800s. It functions as a prodrug that is bioactivated by formation of an enzyme-based thionitrate, E-Cys-NO. This intermediate reportedly decomposes to release NO and NO but their relative yields remain controversial.
View Article and Find Full Text PDFA real-world pharmacovigilance analysis of potential ototoxicity associated with sacubitril/valsartan based on FDA Adverse Event Reporting System (FAERS).
Sci Rep
December 2024
Department of Comprehensive Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Sacubitril/valsartan, a first-in-class angiotensin receptor neprilysin inhibitor, is widely used to treat heart failure. Despite its efficacy, sacubitril/valsartan inevitably causes adverse events such as hypotension, renal dysfunction, hyperkalemia, and angioedema. Sacubitril/valsartan-associated ototoxicity is often underreported in clinical studies and real-world settings.
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